Evidence map›Paper›PMID 36782352›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2023

Polygenic Risk Scores for Alzheimer's Disease and General Cognitive Function Are Associated With Measures of Cognition in Older South Asians.

Wei Zhao, Jennifer A Smith, Yi Zhe Wang, Manjusha Chintalapati, Farah Ammous, Miao Yu, Priya Moorjani, Andrea Ganna, Alden Gross, Sharmistha Dey and 5 more

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 3 countries.

Wei ZhaoDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Jennifer A SmithDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-3575-5468
Yi Zhe WangDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-7630-273X
Manjusha ChintalapatiDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA.
Farah AmmousDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Miao YuDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Priya MoorjaniDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA.
Andrea GannaInstitute for Molecular Medicine Finland, Helsinki, Finland.
Alden GrossJohns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Sharmistha DeyDepartment of Biophysics, All India Institute of Medical Sciences, New Delhi, India.
Joyita BenerjeeDepartment of Geriatric Medicine, All India Institute of Medical Sciences, New Delhi, India.ORCID 0000-0002-3432-9782
Prasun ChatterjeeDepartment of Geriatric Medicine, All India Institute of Medical Sciences, New Delhi, India.
Aparajit B DeyDepartment of Geriatric Medicine, All India Institute of Medical Sciences, New Delhi, India.
Jinkook LeeDepartment of Economics, University of Southern California, Los Angeles, California, USA.
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
University of Michigan · USAll India Institute of Medical Sciences · INUniversity of California, Berkeley · USInstitute for Molecular Medicine Finland · FIJohns Hopkins University · USUniversity of Southern California · US

Funding

Leveraging a natural experiment to estimate the causal impact of blood sugar on dementia and cognition in IndiaR01AG051125 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Jinkook Lee · 2015 to 2026
$26.8M
Harmonized Diagnostic Assessment of Dementia (DAD) for Longitudinal Aging Study of India (LASI)-Genomic study.U01AG064948 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KARDIA, SHARON L, LEE, JINKOOK · 2019 to 2023
$12.5M
Genomic Insights into Human Population Mixture and its Role in Adaptation and DiseaseR35GM142978 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Priya Moorjani · 2021 to 2026
$2.5M
NIA NIH HHS R01 AG051125NIA NIH HHS U01 AG064948NIGMS NIH HHS R35 GM142978
6 · The paper itself

Abstract

Genome-wide association studies (GWAS) conducted in European ancestry (EA) have identified hundreds of single-nucleotide polymorphisms (SNPs) associated with general cognitive function and/or Alzheimer's disease (AD). The association between these SNPs and cognitive function has not been fully evaluated in populations with complex genetic substructure such as South Asians. This study investigated whether SNPs identified in EA GWAS, either individually or as polygenic risk scores (PRSs), were associated with general cognitive function and 5 broad cognitive domains in 932 South Asians from the Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India (LASI-DAD). We found that SNPs identified from AD GWAS were more strongly associated with cognitive function in LASI-DAD than those from a GWAS of general cognitive function. PRSs for general cognitive function and AD explained up to 1.1% of the variability in LASI-DAD cognitive domain scores. Our study represents an important stepping stone toward better characterization of the genetic architecture of cognitive aging in the Indian/South Asian population and highlights the need for further research that may lead to the identification of new variants unique to this population.

Indexed as

Alzheimer DiseaseAgedCognitionGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansPolymorphism, Single NucleotideRisk FactorsSouth Asian PeopleDementiaGenetic risk scoreIndiaPopulation structureSingle-nucleotide polymorphism

Identifiers

PMID36782352
PMCPMC10172981
OpenAlexW4320511663

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.