Evidence map›Paper›PMID 36782153›Full record

ArticleBMC ophthalmology2023

Positive correlation between hypertensive retinopathy and albuminuria in hypertensive adults.

Jun Li, Wenbo Zhang, Liang Zhao, Jing Zhang, Haicheng She, Ying Meng, Yadi Zhang, Xiaopeng Gu, Yan Zhang, Jianping Li and 11 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Albuminuria: An Underappreciated Risk Factor for Cardiovascular Disease.Journal of the American Heart Association · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 9 institutions in 2 countries.

Jun Li *Department of Ophthalmology, Peking University First Hospital, No.8 Xishiku Street, Xicheng District, Beijing, 100034, China.
Wenbo Zhang *Department of Ophthalmology, Peking University First Hospital, No.8 Xishiku Street, Xicheng District, Beijing, 100034, China. wenbo_zhang@bjmu.edu.cn.
Liang ZhaoDepartment of Ophthalmology, Peking University First Hospital, No.8 Xishiku Street, Xicheng District, Beijing, 100034, China.
Jing ZhangDepartment of Ophthalmology, Peking University First Hospital, No.8 Xishiku Street, Xicheng District, Beijing, 100034, China.
Haicheng SheBeijing Ophthalmology and Visual Science Key Laboratory, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Ying MengDepartment of Ophthalmology, Peking University International Hospital, Beijing, China.
Yadi ZhangDepartment of Ophthalmology, Peking University First Hospital, No.8 Xishiku Street, Xicheng District, Beijing, 100034, China.
Xiaopeng GuDepartment of Ophthalmology, Peking University First Hospital, No.8 Xishiku Street, Xicheng District, Beijing, 100034, China.
Yan ZhangDepartment of Cardiology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing, 100034, China.
Jianping LiDepartment of Cardiology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing, 100034, China.
Xianhui QinNational Clinical Research Study Center for Kidney Disease, State Key Laboratory for Organ Failure Research; Renal Division, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Binyan WangInstitute of Biomedicine, Anhui Medical University, Hefei, China.
Xiping XuNational Clinical Research Study Center for Kidney Disease, State Key Laboratory for Organ Failure Research; Renal Division, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Fanfan HouNational Clinical Research Study Center for Kidney Disease, State Key Laboratory for Organ Failure Research; Renal Division, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Genfu TangSchool of Health Administration, Anhui University, Hefei, China.
Rongfeng LiaoDepartment of Ophthalmology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Lishun LiuGraduate School at Shenzhen, Tsinghua University, Shenzhen, China.
Meiqing HuangData Management Center, Shenzhen Evergreen Medical Institute, Shenzhen, China.
Xinlei BaiChina Pharmaceutical University, Nanjing, China.
Yong HuoDepartment of Cardiology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing, 100034, China. huoyong@263.net.cn.
Liu YangDepartment of Ophthalmology, Peking University First Hospital, No.8 Xishiku Street, Xicheng District, Beijing, 100034, China. lucy02114@163.com.
Peking University · CNAnhui Medical University · CNNanfang Hospital · CNPeking University First Hospital · CNAnhui University · CNCapital Medical University · CNChina Pharmaceutical University · CNNational Clinical Research · USUniversity Town of Shenzhen · CN

Funding

the National Key Research and Development Program 2016YFC0903103the National Key Research and Development Program 2016YFE0205400the National Natural Science Foundation of China 81730019the Outstanding Youths Development Scheme of Nanfang Hospital, Southern Medical University 2017J009the Science and Technology Planning Project of Guangzhou 201707020010the Science, Technology and Innovation Committee of Shenzhen JSGG20170412155639040
6 · The paper itself

Abstract

purposeWe investigated the association between albuminuria and hypertensive retinopathy (HR) in hypertensive adults.

methodsThis was a cross-sectional subgroup analysis of data from the China Stroke Primary Prevention Trial. We enrolled 2,964 hypertensive adults in this study. Keith-Wagener-Barker stages was used to assess HR. The urinary albumin to creatinine ratio (UACR) was calculated to evaluate albuminuria.

resultsHR was found in 76.6% (n = 2, 271) of the participants, albuminuria was found in 11.1% (n = 330). The UACR levels were significantly higher in subjects with HR than in those without HR (grade 1, β = 1.42, 95% confidence intervals [CI]: -0.12, 2.95, p = 0.070; grade 2, β = 2.62, 95% CI: 0.56, 4.67, p = 0.013; grade 3, β = 5.17, 95% CI: 1.13, 9.20, p = 0.012). In the subgroup analyses, the association between HR and UACR was stronger in current smokers (p for interaction = 0.014). The correlation between HR grades 1 and 2 and UACR was stronger in subjects with higher triglyceride levels (≥ 1.7 mmol/L), but for grade 3 HR, this correlation was stronger in subjects with lower triglycerides levels (< 1.7 mmol/L, p for interaction = 0.023). The odds of albuminuria were significantly higher in subjects with HR than in those without HR (grade 1, odds ratio [OR] = 1.57, 95% CI: 1.08, 2.29, p = 0.019; grade 2, OR = 2.02, 95% CI: 1.28, 3.18, p = 0.002; grade 3, OR = 2.12, 95% CI: 0.99, 4.55, p = 0.053). In the subgroup analyses, the association between HR grades 1 and 2 and albuminuria was stronger in subjects with higher triglycerides levels (≥ 1.7 mmol/L), but for grade 3 HR, this correlation was stronger in subjects with lower triglyceride levels (< 1.7 mmol/L, p for interaction = 0.014).

conclusionHR was positively correlated with albuminuria in hypertensive Chinese adults. This correlation was more remarkable when the population was stratified by triglycerides levels and smoking status. HR can be used as an indicator of early renal injury.

Indexed as

HypertensionHypertensive RetinopathyAdultAlbuminuriaCross-Sectional StudiesHumansTriglyceridesTriglyceridesAlbuminuriaHypertensionHypertensive retinopathyUrinary albumin to creatinine ratio

Identifiers

PMID36782153
PMCPMC9923927
OpenAlexW4320489729

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.