Evidence map›Paper›PMID 36782067›Full record

ArticlePediatric research2023

Critical congenital heart disease beyond HLHS and TGA: neonatal brain injury and early neurodevelopment.

Rachel Vassar, Shabnam Peyvandi, Dawn Gano, Stephany Cox, Yensy Zetino, Steven Miller, Patrick McQuillen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Rachel VassarDivision of Pediatric Neurology, Department of Neurology, Benioff Children's Hospital, University of California, San Francisco, CA, USA. rachel.vassar@ucsf.edu.
Shabnam PeyvandiDivision of Pediatric Cardiology, Department of Pediatrics, Benioff Children's Hospital, University of California, San Francisco, CA, USA.
Dawn GanoDivision of Pediatric Neurology, Department of Neurology, Benioff Children's Hospital, University of California, San Francisco, CA, USA.
Stephany CoxDivision of Pediatric Cardiology, Department of Pediatrics, Benioff Children's Hospital, University of California, San Francisco, CA, USA.
Yensy ZetinoDivision of Pediatric Cardiology, Department of Pediatrics, Benioff Children's Hospital, University of California, San Francisco, CA, USA.
Steven MillerDepartment of Neurology, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Patrick McQuillenDivision of Critical Care, Department of Pediatrics, Benioff Children's Hospital, University of California, San Francisco, CA, USA.
UCSF Benioff Children's Hospital · USUniversity of Toronto · CA

Funding

Repair in High Risk Newborns with Congential Heart DiseaseP01NS082330 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI XU, DUAN · 2014 to 2018
$6.0M
Fetal markers of neurodevelopmental outcomes in congenital heart diseaseK23NS099422 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PEYVANDI, SHABNAM · 2017 to 2021
$961k
NINDS NIH HHS K23 NS099422NINDS NIH HHS P01 NS082330
6 · The paper itself

Abstract

backgroundCharacterization of brain injury and neurodevelopmental (ND) outcomes in critical congenital heart disease (cCHD) has primarily focused on hypoplastic left heart syndrome (HLHS) and transposition of the great arteries (TGA). This study reports brain injury and ND outcomes among patients with heterogeneous cCHD diagnoses beyond HLHS and TGA.

methodsThis prospective cohort study included infants with HLHS, TGA, or heterogenous "Other cCHD" including left- or right-sided obstructive lesions, anomalous pulmonary venous return, and truncus arteriosus. Brain injury on perioperative brain MRI and ND outcomes on the Bayley-II at 30 months were compared.

resultsA total of 218 participants were included (HLHS = 60; TGA = 118; "Other cCHD" = 40, including 8 with genetic syndromes). Pre-operative (n = 209) and post-operative (n = 189) MRI showed similarly high brain injury rates across groups, regardless of cardiopulmonary bypass exposure. At 30 months, participants with "Other cCHD" had lower cognitive scores (p = 0.035) compared to those with HLHS and TGA, though worse ND outcome in this group was driven by those with genetic disorders.

conclusionsFrequency of brain injury and neurodevelopmental delay among patients with "Other cCHD" is similar to those with HLHS or TGA. Patients with all cCHD lesions are at risk for impaired outcomes; developmental and genetic screening is indicated. IMPACT: This study adds to literature on risk of brain injury in patients with critical congenital heart disease (cCHD) diagnoses other than hypoplastic left heart syndrome (HLHS) and transposition of the great arteries (TGA), a heterogenous cohort of patients that has often been excluded from imaging studies. Children with cCHD beyond HLHS and TGA have similarly high rates of acquired brain injury. The high rate of neurodevelopmental impairment in this heterogenous group of cCHD diagnoses beyond HLHS and TGA is primarily driven by patients with comorbid genetic syndromes such as 22q11.2 deletion syndrome.

Indexed as

Brain InjuriesHeart Defects, CongenitalHypoplastic Left Heart SyndromeTransposition of Great VesselsChildHumansInfantInfant, NewbornProspective Studies

Identifiers

PMID36782067
PMCPMC10403377
OpenAlexW4320490208

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.