Evidence map›Paper›PMID 36782057›Full record

ArticleEye (London, England)2023

Retinal neovascularization as self-organized criticality on ultra-widefield fluorescein angiography imaging of diabetic retinopathy.

Benjamin K Young, Nikhil Bommakanti, Gina Yu, Tapan P Patel, Lyna Azzouz, Corey Powell, Yannis M Paulus

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Eye (London, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Benjamin K YoungDepartment of Ophthalmology and Visual Sciences, W.K. Kellogg Eye Center, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0000-0002-5425-2401
Nikhil BommakantiDepartment of Ophthalmology and Visual Sciences, W.K. Kellogg Eye Center, University of Michigan Medical School, Ann Arbor, MI, USA.
Gina YuDepartment of Ophthalmology and Visual Sciences, W.K. Kellogg Eye Center, University of Michigan Medical School, Ann Arbor, MI, USA.
Tapan P PatelDepartment of Ophthalmology and Visual Sciences, W.K. Kellogg Eye Center, University of Michigan Medical School, Ann Arbor, MI, USA.
Lyna AzzouzDepartment of Ophthalmology and Visual Sciences, W.K. Kellogg Eye Center, University of Michigan Medical School, Ann Arbor, MI, USA.
Corey PowellDepartment of Ophthalmology and Visual Sciences, W.K. Kellogg Eye Center, University of Michigan Medical School, Ann Arbor, MI, USA.
Yannis M PaulusDepartment of Ophthalmology and Visual Sciences, W.K. Kellogg Eye Center, University of Michigan Medical School, Ann Arbor, MI, USA. ypaulus@med.umich.edu.ORCID 0000-0002-0615-628X

Funding

Multimodal Molecular Imaging of Choroidal NeovascularizationR01EY034325 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Yannis Mantas Paulus, XUEDING WANG · 2023 to 2026
$2.5M
Development of Nanoneedle Array for Painless and Long-Term Sustained Intraocular Drug DeliveryR01EY033000 · NEI · PURDUE UNIVERSITY · PI LEE, CHI HWAN, PAULUS, YANNIS MANTAS · 2021 to 2025
$1.9M
Real-time In Vivo Visualization of the Molecular Processes in Choroidal NeovascularizationK08EY027458 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PAULUS, YANNIS MANTAS · 2018 to 2021
$898k
NEI NIH HHS K08 EY027458NEI NIH HHS R01 EY033000NEI NIH HHS R01 EY034325
6 · The paper itself

Abstract

BACKGROUND/

objectivesDo the distributions of surface area of non-perfusion (NP) and neovascularization (NV) on ultra-widefield fluorescein angiography (UWF FA) in patients with diabetic retinopathy (DR) differ significantly? SUBJECTS/

methodsInclusion criteria were patients who had a UWF FA taken for DR at the Kellogg Eye Center from January 2009 to May 2018. Exclusion criteria included previous panretinal photocoagulation and significant media opacity (e.g., vitreous haemorrhage or significant cataract). UWF FAs were manually segmented for surface areas of NP and NV. The total areas per patient were organized in a histogram, and logarithmically binned to test against power law and exponential distributions. Then, a computational model was constructed in Python 3.7 to suggest a mechanistic explanation for the observed distributions.

resultsAnalysis of areas of NV across 189 images demonstrated a superior fit by the least squares method to a power law distribution (p = 0.014) with an R

conclusionsThese distributions inform what useful statistics may be applied to study of these imaging characteristics. Further, the difference in event distribution between NV and NP suggests that the two phenomena are mechanistically distinct. NV may follow SOC, propagating as a catastrophic event in an unpredictable manner.

Indexed as

Diabetes MellitusDiabetic RetinopathyRetinal NeovascularizationFluorescein AngiographyHumansRetinal VesselsTomography, Optical Coherence

Identifiers

PMID36782057
PMCPMC10482976

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.