ArticleScientific reports2023
Performance of classification and diagnostic criteria for IgG4-related disease and comparison of patients with and without IgG4-related disease.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Diagnostic accuracy of IgG 4/IgG and IgG 4 in patients with IgG 4-related disease: a meta-analysis.Zeitschrift fur Rheumatologie · 2025Pooled it
- Diagnostic Imaging of Pancreatic and Biliary Involvement in IgG4-Related Disease: Key Imaging Features, Diagnostic Criteria and Differential Diagnosis.Diagnostics (Basel, Switzerland) · 2026Review
- Type 1 autoimmune pancreatitis (IgG4-related disease) presenting as new-onset diabetes mellitus: a case report.Journal of medical case reports · 2026Article
- Isolated Mediastinal and Hilar Lymphadenopathy as a Manifestation of IgG4-Related Disease Diagnosed by EBUS-Guided Transbronchial Mediastinal Cryobiopsy.Respirology case reports · 2026Article
- Rare Presentation of Immunoglobulin G4-Related Disease: Hepatic Mass Lesions Mimicking Metastasis.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2025Article
- IgG4-Related Disease: Current and Future Insights into Pathological Diagnosis.International journal of molecular sciences · 2025Review
- IgG4-related disease and other fibro-inflammatory conditions.Nature reviews. Rheumatology · 2025Review
- Immunopathological syndromes: state of the art.Frontiers in medicine · 2025Review
- [Immunoglobulin G4 disease with pancreatic affectation: the mimicker of malignancy].Revista medica del Instituto Mexicano del Seguro Social · 2024Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
IgG4-related disease (IgG4-RD) was recently described in Japan. It is characterised by extensive organ involvement with tissue fibrosis. We assessed the performance of the 2019 American College of Rheumatology and European League Against Rheumatism (ACR/EULAR) classification criteria and the 2020 revised comprehensive diagnostic (RCD) criteria as well as differences between patients with and without IgG4-RD. In this retrospective, single-centre study of 50 patients admitted with suspected IgG4-RD, we evaluated the sensitivity and specificity of both criteria. We also compared clinical characteristics and laboratory data of patients with IgG4-RD (n = 42) and patients without IgG4-RD (n = 8). The ACR/EULAR classification criteria had 88.1% sensitivity and 87.5% specificity for IgG4-RD diagnosis. The RCD criteria had 100% sensitivity and 50% specificity. Patients with IgG4-RD had significantly more affected organs (p = 0.002). Patients with a single affected organ and IgG4-RD had significantly higher serum IgG4/IgG ratios (p = 0.027), lower serum C-reactive protein levels (p = 0.020), and lower total haemolytic complement activity (p = 0.044) than those without IgG4-RD. The ACR/EULAR classification criteria have high specificity and the RCD criteria have high sensitivity for diagnosing IgG4-RD. The number of affected organs is important for diagnosing IgG4-RD.
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