Evidence map›Paper›PMID 36782003›Full record

ArticleScientific reports2023

Thioquinoline derivatives conjugated to thiosemicarbazide as potent tyrosinase inhibitors with anti-melanogenesis properties.

Milad Noori, Reyhaneh Sabourian, Ali Tasharoie, Maliheh Safavi, Aida Iraji, Minoo Khalili Ghomi, Navid Dastyafteh, Cambyz Irajie, Elham Zarenezhad, Seyyed Mehrdad Mostafavi Pour and 5 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Enzymatic, cell-based, andRSC advances · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Design, synthesis, andRSC advances · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Design, synthesis,Heliyon · 2023
    Article
  11. Heterocyclic Compounds as Synthetic Tyrosinase Inhibitors: Recent Advances.International journal of molecular sciences · 2023
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Milad NooriEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Reyhaneh SabourianDrug and Food Control Department, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Ali TasharoieDrug and Food Control Department, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Maliheh SafaviDepartment of Biotechnology, Iranian Research Organization for Science and Technology (IROST), Tehran, Iran.
Aida IrajiStem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Minoo Khalili GhomiEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Navid DastyaftehEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Cambyz IrajieDepartment of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.
Elham ZarenezhadStem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Seyyed Mehrdad Mostafavi PourLiosa Pharmed Parseh Company, Shiraz, Iran.
Fatemeh RasekhDepartment of Biology, Payame Noor University(PNU), Tehran, Iran.
Bagher LarijaniEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Mohsen AminiDepartment of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Mannan HajimahmoodiDrug and Food Control Department, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. hajimah@tums.ac.ir.
Mohammad MahdaviEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. momahdavi@sina.tums.ac.ir.
Tehran University of Medical Sciences · IRShiraz University of Medical Sciences · IRIranian Research Organization for Science and Technology · IRPayame Noor University · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the present study, a series of aryl-substituted thioqunoline conjugated to thiosemicarbazide were rationally designed and synthesized. The formation of target compounds was confirmed by spectral characterization techniques such as IR,

Indexed as

AgaricalesEnzyme InhibitorsMonophenol MonooxygenaseMelaninsMolecular Docking SimulationMolecular StructureSemicarbazidesStructure-Activity RelationshipEnzyme InhibitorsMelaninsMonophenol MonooxygenaseSemicarbazidesthiosemicarbazide

Identifiers

PMID36782003
PMCPMC9925432
OpenAlexW4320483661

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.