ArticleScientific reports2023
Factors associated with plasmid antibiotic resistance gene carriage revealed using large-scale multivariable analysis.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Patterns of antimicrobial resistance genes in pathogens across One Health sectors in Ireland: anMicrobiology spectrum · 2026Article
- Host Range Breadth Correlates with Genic Diversity in Honeybee Phages.Genome biology and evolution · 2026Article
- A nutritional link to antimicrobial resistance: iron scarcity promotes plasmid co-selection inApplied and environmental microbiology · 2026Article
- Antimicrobial Armageddon: The Professional Guide to Conquering Antibiotic Resistance.Probiotics and antimicrobial proteins · 2026Article
- Nested mobile genetic elements mediating antimicrobial resistance genes mobility within and betweeniScience · 2026Article
- A novel self-transmissible mega plasmid from extensively drug-resistantCurrent research in microbial sciences · 2026Article
- Plasmid-mediated carbapenem resistance: global dissemination patterns and replicon-gene associations.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- Article
- Pathogen virulence genes: Advances, challenges and future directions in infectious disease research (Review).International journal of molecular medicine · 2025Review
- The Role of Livestock Antibiotic Use in Microbiota Dysbiosis and Neuroinflammation.Antibiotics (Basel, Switzerland) · 2025Review
- Phenotypic and Genomic Assessment of Antimicrobial Resistance and Virulence Factors Determinants inAnimals : an open access journal from MDPI · 2025Article
- Encounter rates and engagement times limit the transmission of conjugative plasmids.PLoS genetics · 2025Article
- Genomic diversity and evolutionary patterns ofMicrobial genomics · 2025Article
- Exploring the bacterial diversity and its antibiotic resistance in Kabru Glacier ice cores, Sikkim Himalaya.Frontiers in microbiology · 2025Article
- Unraveling the role of mobile genetic elements in antibiotic resistance transmission and defense strategies in bacteria.Frontiers in systems biology · 2025Review
- Genomic insights into antimicrobial resistance and virulence ofFrontiers in microbiology · 2025Article
- Antibacterial Properties of Peptide and Protein Fractions fromMolecules (Basel, Switzerland) · 2024Article
- A multi-species outbreak of VIM-producing carbapenem-resistant bacteria in a burn unit and subsequent investigation of rapid development of cefiderocol resistance.Antimicrobial agents and chemotherapy · 2024Article
- Review of antibiotic-resistant bacteria and antibiotic resistance genes within the one health framework.Infection ecology & epidemiology · 2024Review
- Antimicrobial Resistance: Addressing a Global Threat to Humanity.PLoS medicine · 2023Article
Corrections and comments
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Authors and funding
5 authors at 5 institutions in 1 country.
Funding
Abstract
Plasmids are major vectors of bacterial antibiotic resistance, but understanding of factors associated with plasmid antibiotic resistance gene (ARG) carriage is limited. We curated > 14,000 publicly available plasmid genomes and associated metadata. Duplicate and replicate plasmids were excluded; where possible, sample metadata was validated externally (BacDive database). Using Generalised Additive Models (GAMs) we assessed the influence of 12 biotic/abiotic factors (e.g. plasmid genetic factors, isolation source, collection date) on ARG carriage, modelled as a binary outcome. Separate GAMs were built for 10 major ARG types. Multivariable analysis indicated that plasmid ARG carriage patterns across time (collection years), isolation sources (human/livestock) and host bacterial taxa were consistent with antibiotic selection pressure as a driver of plasmid-mediated antibiotic resistance. Only 0.42% livestock plasmids carried carbapenem resistance (compared with 12% human plasmids); conversely, tetracycline resistance was enriched in livestock vs human plasmids, reflecting known prescribing practices. Interpreting results using a timeline of ARG type acquisition (determined by literature review) yielded additional novel insights. More recently acquired ARG types (e.g. colistin and carbapenem) showed increases in plasmid carriage during the date range analysed (1994-2019), potentially reflecting recent onset of selection pressure; they also co-occurred less commonly with ARGs of other types, and virulence genes. Overall, this suggests that following acquisition, plasmid ARGs tend to accumulate under antibiotic selection pressure and co-associate with other adaptive genes (other ARG types, virulence genes), potentially re-enforcing plasmid ARG carriage through co-selection.
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Registered trials
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