ArticleNature communications2023
Electroacupuncture improves swallowing function in a post-stroke dysphagia mouse model by activating the motor cortex inputs to the nucleus tractus solitarii through the parabrachial nuclei.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 9 of them syntheses that pooled it.
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Who cites it
63 citing papers in PubMed, 9 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Data mining of acupoint selection and combination patterns for dysphagia with sialorrhea: a literature-based study.Frontiers in neurology · 2026Pooled it
- Sustained efficacy of acupuncture in post-stroke dysphagia: a systematic review and meta-analysis.Frontiers in neurology · 2026Pooled it
- Neuromuscular-related interventions for post-stroke dysphagia: a comprehensive narrative review.Frontiers in neuroscience · 2026Pooled it
- Efficacy of acupuncture for stroke-associated pneumonia: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- The effect of acupuncture combined with hyperbaric oxygenation compared with hyperbaric oxygenation alone for patients with traumatic brain injury: a systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- The efficacy of acupuncture for post-stroke dysphagia: an overview of systematic reviews and meta-analyses.Frontiers in neuroscience · 2025Pooled it
- Research hotspots and frontiers in post-stroke dysphagia: a bibliometric analysis study.Frontiers in neurology · 2024Pooled it
- Systematic review and meta-analysis of the efficacy and safety of electroacupuncture for poststroke dysphagia.Frontiers in neurology · 2023Pooled it
- Effectiveness of nape acupuncture for post-stroke dysphagia: a meta-analysis and trial sequential analysis of randomized controlled trials.Frontiers in neurologyPooled it
- Efficacy and Mechanisms of Combined Central-Peripheral Magnetic Stimulation on Prefrontal-Sensorimotor Cortex Connectivity in Post-Stroke Dysphagia after Supratentorial Stroke: A Randomized, Single-Blind, Parallel-Controlled Trial.Translational stroke research · 2026Trial
- Effects of Transcutaneous Auricular Vagus Nerve Stimulation on Swallowing Function in Post-stroke Dysphagia: A Randomized Controlled Study.Translational stroke research · 2026Trial
- Transcranial Direct Current Stimulation Over the Vagus Nerve Promotes Poststroke Dysphagia Recovery: A Randomized, Double-Blind, Sham-Controlled Clinical Trial.American journal of physical medicine & rehabilitation · 2026Trial
- Effects of Acupuncture Combined with Conventional Rehabilitation Training for Patients with Post-Stroke Dysphagia: A Randomized Controlled Trial.Journal of multidisciplinary healthcare · 2025Trial
- Distinct brain susceptibility alteration pattern in Parkinson's disease with drooling: evidence from quantitative susceptibility mapping.Quantitative imaging in medicine and surgery · 2026Article
- Restoration of Excitation-Inhibition Balance and Improvement of Schizophrenia-like Behavioral Deficits via Electroacupuncture.CNS neuroscience & therapeutics · 2026Article
- Case Report: Improvement in Swallowing Function Following DLPFC-Targeted Repetitive Transcranial Magnetic Stimulation in a Post-Stroke Patient with Cognitive Impairment.Journal of clinical medicine · 2026Article
- Transient receptor potential vanilloid 4 channels contribute to the initiation of water-induced swallowing reflexes.Scientific reports · 2026Article
- Electroacupuncture inhibited neuronal apoptosis through PGAM5/FUNDC1-dependent mitophagy after ischemic stroke.Chinese medicine · 2026Article
- Transient receptor potential vanilloid 4 channels contribute to the initiation of water-induced swallowing reflexes.Research square · 2026Article
- Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
16 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As a traditional medical therapy, stimulation at the Lianquan (CV23) acupoint, located at the depression superior to the hyoid bone, has been shown to be beneficial in dysphagia. However, little is known about the neurological mechanism by which this peripheral stimulation approach treats for dysphagia. Here, we first identified a cluster of excitatory neurons in layer 5 (L5) of the primary motor cortex (M1) that can regulate swallowing function in male mice by modulating mylohyoid activity. Moreover, we found that focal ischemia in the M1 mimicked the post-stroke dysphagia (PSD) pathology, as indicated by impaired water consumption and electromyographic responses in the mylohyoid. This dysfunction could be rescued by electroacupuncture (EA) stimulation at the CV23 acupoint (EA-CV23) in a manner dependent on the excitatory neurons in the contralateral M1 L5. Furthermore, neuronal activation in both the parabrachial nuclei (PBN) and nucleus tractus solitarii (NTS), which was modulated by the M1, was required for the ability of EA-CV23 treatment to improve swallowing function in male PSD model mice. Together, these results uncover the importance of the M1-PBN-NTS neural circuit in driving the protective effect of EA-CV23 against swallowing dysfunction and thus reveal a potential strategy for dysphagia intervention.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.