Evidence map›Paper›PMID 36781561›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2023

The imbalance between Bregs, Tfh, and Tregs in patients with anti-N-methyl-D-aspartate receptor encephalitis.

Yatong Li, Jing Zhang, Lei Liu, Shilei Cui, Houliang Sun, Hanqiu Jiang, Yanjun Guo, Jingxiao Zhang, Zhuxiao Xie, Jiawei Wang

Open access · hybridAbstract read
In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Yatong LiDepartment of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Jing ZhangClinical Research Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Lei LiuDepartment of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Shilei CuiDepartment of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Houliang SunDepartment of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Hanqiu JiangDepartment of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Yanjun GuoDepartment of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Jingxiao ZhangDepartment of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Zhuxiao XieDepartment of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Jiawei WangDepartment of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. wangjwcq@163.com.ORCID http://orcid.org/0000-0002-4716-928X
Beijing Tongren Hospital · CN

Funding

Beijing Hospitals Authority Youth Program QML20150206Beijing Municipal Natural Science Foundation 7192040Beijing Science and Technology Project Z171100001017039Beijing Tongren Hospital, Capital Medical University, Key Medical Development Plan TRYY-KYJJ-2017-054Key Projects of Medical Development in Capital 2014-1-1101Key Research and Development Plan of the Ministry of Science and Technology of the People's Republic of China 2016YFC0904502National Natural Science Foundation of China 81771313
6 · The paper itself

Abstract

objectiveTo detect the alteration of regulatory B cells (Bregs), follicular helper T cells (Tfh), and regulatory T cells (Tregs) frequencies in patients with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis. Analyze their association with clinical severity and activity, and explore the effects of different immunotherapies on those immune cell subsets.

methodsWe enrolled 21 patients with anti-NMDAR encephalitis, 22 patients with neuromyelitis optica spectrum disorder (NMOSD), 14 patients with idiopathic intracranial hypertension (IIH), and 20 healthy controls (HC) in our study. The frequencies of various immune cell subsets were determined using flow cytometry.

resultsCompared to patients with IIH and HC, the frequencies of CD24

conclusionWe suggested that the frequencies of CD24

Indexed as

Anti-N-Methyl-D-Aspartate Receptor EncephalitisB-Lymphocytes, RegulatoryNeuromyelitis OpticaFlow CytometryHumansT Follicular Helper CellsT-Lymphocytes, RegulatoryAnti-N-methyl-D-aspartate receptor encephalitisBregsTfhTregs

Identifiers

PMID36781561
PMCPMC10257618
OpenAlexW4320710500

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.