Evidence map›Paper›PMID 36781468›Full record

SynthesisSurgical endoscopy2023

European Association for Endoscopic Surgery (EAES) consensus on Indocyanine Green (ICG) fluorescence-guided surgery.

E Cassinotti, M Al-Taher, S A Antoniou, A Arezzo, L Baldari, L Boni, M A Bonino, N D Bouvy, R Brodie, T Carus and 21 more

Registry-linked trialOpen access · hybridFull text readSystematic ReviewConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Surgical endoscopy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07638956 (A Prospective Study of Indocyanine Green), which is not on this map. Cited by 70 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 9 pooled it
23.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07638956 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Prospective Study of Indocyanine Green (ICG) Fluorescence-Guided Lymphatic Mapping During Laparoscopic Colon Cancer Resection

TypeinterventionalSponsorTanta UniversityRan2026 to 2028Enrolled25ConditionsColon Cancer, ICG (Indocyanine Green)ArmsIndocyanine green (ICG) injection for intraoperative lymph node imaging, Laparoscopic Colon Cancer Resection
3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 9 syntheses or guidelines pooled it, 102 citations in OpenAlex.

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  20. Use of indocyanine green in thoracic surgery: a literature review.Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery · 2026
    Review

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors at 19 institutions in 10 countries.

E CassinottiDepartment of General and Minimally Invasive Surgery, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, University of Milan, Via Francesco Sforza 35, 20121, Milan, Italy. elisa.cassinotti@unimi.it.ORCID http://orcid.org/0000-0003-3780-6561
M Al-TaherResearch Institute Against Digestive Cancer (IRCAD), Strasbourg, France.
S A AntoniouDepartment of Surgery, Papageorgiou General Hospital, Thessaloniki, Greece.
A ArezzoDepartment of Surgical Sciences, University of Torino, Turin, Italy.
L BaldariDepartment of General and Minimally Invasive Surgery, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, University of Milan, Via Francesco Sforza 35, 20121, Milan, Italy.
L BoniDepartment of General and Minimally Invasive Surgery, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, University of Milan, Via Francesco Sforza 35, 20121, Milan, Italy.
M A BoninoDepartment of Surgery, Geneva University Hospitals, Geneva, Switzerland.
N D BouvyDepartment of Surgery, Maastricht University Medical Center, Maastricht, The Netherlands.
R BrodieDepartment of General Surgery, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
T CarusNiels-Stensen-Kliniken, Elisabeth-Hospital, Thuine, Germany.
M ChandWellcome/EPSRC Centre for Interventional and Surgical Sciences (WEISS), University College London, London, UK.
M DianaIHU Strasbourg, Institute of Image-Guided Surgery and IRCAD, Research Institute Against Cancer of the Digestive System, Strasbourg, France.
M M M EussenDepartment of Surgery, Maastricht University Medical Center, Maastricht, The Netherlands.
N FrancisDepartment of General Surgery, Yeovil District Hospital NHS Foundation Trust, Yeovil, UK.
A GuidaDepartment of Medico-Surgical Sciences and Translation Medicine, Faculty of Medicine and Psychology, Sapienza University of Rome, Rome, Italy.
P GonteroDivision of Urology, Department of Surgical Science, AOU Città della Salute e della Scienza di Torino, University of Turin, Turin, Italy.
C M HaneyDepartment of General, Visceral, and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany.
M JansenDepartment of Surgery, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Y MintzDepartment of General Surgery, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
S Morales-CondeUnit of Innovation in Minimally Invasive Surgery, Department of General Surgery, University Hospital Virgen del Rocío, University of Sevilla, Seville, Spain.
B P Muller-StichDepartment of General, Visceral, and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany.
K NakajimaDepartment of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
F NickelDepartment of General, Visceral, and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany.
M OderdaDivision of Urology, Department of Surgical Science, AOU Città della Salute e della Scienza di Torino, University of Turin, Turin, Italy.
P PariseU.O.C. Chirurgia Generale, Policlinico di Abano Terme, Abano Terme, PD, Italy.
R RosatiDepartment of Gastrointestinal Surgery, San Raffaele Hospital, Milan, Italy.
M P SchijvenDepartment of Surgery, Amsterdam UMC, University of Amsterdam, Amsterdam, North Holland, The Netherlands.
G SilecchiaDepartment of Medico-Surgical Sciences and Translation Medicine, Faculty of Medicine and Psychology, Sapienza University of Rome, Rome, Italy.
A S SoaresWellcome/EPSRC Centre for Interventional and Surgical Sciences (WEISS), University College London, London, UK.
S UrakawaDepartment of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
N VettorettoU.O.C. Chirurgia Generale, ASST Spedali Civili di Brescia P.O. Montichiari, Ospedale di Montichiari, Montichiari, Italy.
Heidelberg University · DEUniversity of Milan · ITUniversity of Turin · ITInstitut de Recherche contre les Cancers de l’Appareil Digestif · FRMaastricht University · NLSapienza University of Rome · ITThe University of Osaka · JPWellcome / EPSRC Centre for Interventional and Surgical Sciences · GBAmsterdam University Medical Centers · NLAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITGGD Amsterdam · NLHadassah Medical Center · ILHebrew University of Jerusalem · ILHospital Universitario Virgen del Rocío · ESPapageorgiou General Hospital · GRPoliclinico Abano Terme · ITUniversity Hospital of Geneva · CHVita-Salute San Raffaele University · ITYeovil District Hospital NHS Foundation Trust · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn recent years, the use of Indocyanine Green (ICG) fluorescence-guided surgery during open and laparoscopic procedures has exponentially expanded across various clinical settings. The European Association of Endoscopic Surgery (EAES) initiated a consensus development conference on this topic with the aim of creating evidence-based statements and recommendations for the surgical community.

methodsAn expert panel of surgeons has been selected and invited to participate to this project. Systematic reviews of the PubMed, Embase and Cochrane libraries were performed to identify evidence on potential benefits of ICG fluorescence-guided surgery on clinical practice and patient outcomes. Statements and recommendations were prepared and unanimously agreed by the panel; they were then submitted to all EAES members through a two-rounds online survey and results presented at the EAES annual congress, Barcelona, November 2021.

resultsA total of 18,273 abstracts were screened with 117 articles included. 22 statements and 16 recommendations were generated and approved. In some areas, such as the use of ICG fluorescence-guided surgery during laparoscopic cholecystectomy, the perfusion assessment in colorectal surgery and the search for the sentinel lymph nodes in gynaecological malignancies, the large number of evidences in literature has allowed us to strongly recommend the use of ICG for a better anatomical definition and a reduction in post-operative complications.

conclusionsOverall, from the systematic literature review performed by the experts panel and the survey extended to all EAES members, ICG fluorescence-guided surgery could be considered a safe and effective technology. Future robust clinical research is required to specifically validate multiple organ-specific applications and the potential benefits of this technique on clinical outcomes.

Indexed as

Cholecystectomy, LaparoscopicLaparoscopyFluorescenceHumansIndocyanine GreenIndocyanine GreenConsensusFluorescence-guided surgeryICGIndocyanine greenLaparoscopic surgeryStatement recommendation

Identifiers

PMID36781468
PMCPMC10017637
OpenAlexW4320484045

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read40
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.