Evidence map›Paper›PMID 36781426›Full record

ArticleEuropean journal of applied physiology2023

Short bouts of walking attenuates the response of IL-8 to prolonged sitting in healthy adults.

Nicholas O'Rourke, Emmeline Meens-Miller, Michael Jeffrey, Lin Saleem, Julia Green-Johnson, Shilpa Dogra

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Article in European journal of applied physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nicholas O'RourkeFaculty of Health Sciences (Kinesiology), University of Ontario Institute of Technology, 2000 Simcoe Street North, Oshawa, ON, L1G 0C5, Canada.ORCID http://orcid.org/0000-0003-1571-8894
Emmeline Meens-MillerFaculty of Health Sciences (Kinesiology), University of Ontario Institute of Technology, 2000 Simcoe Street North, Oshawa, ON, L1G 0C5, Canada.
Michael JeffreyFaculty of Science (Biology), University of Ontario Institute of Technology, 2000 Simcoe Street North, Oshawa, ON, L1G 0C5, Canada.
Lin SaleemFaculty of Science (Biology), University of Ontario Institute of Technology, 2000 Simcoe Street North, Oshawa, ON, L1G 0C5, Canada.
Julia Green-JohnsonFaculty of Science (Biology), University of Ontario Institute of Technology, 2000 Simcoe Street North, Oshawa, ON, L1G 0C5, Canada.
Shilpa DograFaculty of Health Sciences (Kinesiology), University of Ontario Institute of Technology, 2000 Simcoe Street North, Oshawa, ON, L1G 0C5, Canada. Shilpa.dogra@uoit.ca.

Funding

Natural Sciences and Engineering Research DDG-2021-00007
6 · The paper itself

Abstract

purposeExperimental studies have shown that prolonged sitting for 2-8 h can cause changes to vascular and metabolic markers; the response of pro-inflammatory cytokines is relatively unexplored. The purpose of this study is to determine the response of interleukin-8 (IL-8) to prolonged and interrupted sitting.

methodsHealthy participants (n = 24, 21.1 years ± 2.2, 50% female) completed a prolonged sitting session (4 h) and an interrupted sitting session (4 h of sitting with 3 min of walking at 60%HRmax, every 30 min) in random order. Saliva and capillary plasma were collected at the beginning (T1) and at the end of each session (T2).

resultsSalivary concentrations of IL-8 increased during the prolonged (T1 median: 22.09 pg/mL, T2 median: 86.18 pg/mL; p =  < 0.01, ES - 0.55) and interrupted (T1 median: 22.09 pg/mL, T2 median: 51.99 pg/mL; p = 0.021, ES - 0.34) sessions; however, the increase during interrupted sitting was lower (PS median: 134.4%, range: - 43.96 to 1115.69 and IS median: 50.8%, range: - 75.5 to 356.35; p = 0.011, ES - 0.53). In the sub-sample of males, salivary IL-8 did not increase in the interrupted session (T1 median: 22.09, range: 3.496-699.12, and T2 median: 24.96, range: 5.11-533.5, p =  > 0.05, ES - 0.16). No significant findings were observed for IL-8 in the plasma.

conclusionProlonged sitting appears to increase concentrations of the pro-inflammatory cytokine IL-8 while interrupting this sitting with short bouts of walking blunts this response. Sex appears to moderate this relationship; however, there appears to be a large amount of individual variability.

Indexed as

Interleukin-8CytokinesFemaleHumansMaleSedentary BehaviorWalkingYoung AdultCXCL8 protein, humanCytokinesInterleukin-8IL-8/CXCL8InflammationInterrupted sittingProlonged sittingSalivary cytokinesSedentary physiology

Identifiers

PMID36781426

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.