Evidence map›Paper›PMID 36781401›Full record

ArticleArchives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists2023

Poorer Inhibitory Control Uniquely Contributes to Greater Functional Disability in Post-9/11 Veterans.

Joseph DeGutis, Sam Agnoli, John P K Bernstein, Audreyana Jagger-Rickels, Travis C Evans, Catherine B Fortier, Regina E McGlinchey, William P Milberg, Michael Esterman

Open access · hybridAbstract read
In one paragraph

Article in Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Joseph DeGutisTranslational Research Center for TBI and Stress Disorders (TRACTS) and Geriatric Research, Education and Clinical Center (GRECC), VA Boston Health Care System, Boston, MA, USA.
Sam AgnoliTranslational Research Center for TBI and Stress Disorders (TRACTS) and Geriatric Research, Education and Clinical Center (GRECC), VA Boston Health Care System, Boston, MA, USA.
John P K BernsteinTranslational Research Center for TBI and Stress Disorders (TRACTS) and Geriatric Research, Education and Clinical Center (GRECC), VA Boston Health Care System, Boston, MA, USA.
Audreyana Jagger-RickelsBoston Attention and Learning (BAL) Lab, VA Boston Health Care System, Boston, MA, USA.
Travis C EvansBoston Attention and Learning (BAL) Lab, VA Boston Health Care System, Boston, MA, USA.
Catherine B FortierTranslational Research Center for TBI and Stress Disorders (TRACTS) and Geriatric Research, Education and Clinical Center (GRECC), VA Boston Health Care System, Boston, MA, USA.
Regina E McGlincheyTranslational Research Center for TBI and Stress Disorders (TRACTS) and Geriatric Research, Education and Clinical Center (GRECC), VA Boston Health Care System, Boston, MA, USA.
William P MilbergTranslational Research Center for TBI and Stress Disorders (TRACTS) and Geriatric Research, Education and Clinical Center (GRECC), VA Boston Health Care System, Boston, MA, USA.
Michael EstermanBoston Attention and Learning (BAL) Lab, VA Boston Health Care System, Boston, MA, USA.
Harvard University · USVA Boston Healthcare System · USGeriatric Research Education and Clinical Center · USBoston University · US

Funding

Neurobiological & Clinical Phenotypes in OEF/OIF/OND Veterans with mTBI or BlastR21AT009430 · NCCIH · HARVARD MEDICAL SCHOOL · PI MILBERG, WILLIAM P · 2016 to 2017
$356k
CSRD VA I01 CX001653NCCIH NIH HHS R21 AT009430NCCIH NIH HHS R21 AT009430-01NIH HHS 2T32MH01983621
6 · The paper itself

Abstract

objectivePost-9/11 Veterans endorse greater self-reported functional disability than 80% of the adult population. Previous studies of trauma-exposed populations have shown that increased post-traumatic stress disorder (PTSD) and depressive symptoms are consistently associated with greater disability. Additionally, poorer cognitive performance in the domain of executive functions, particularly inhibitory control, has been associated with disability, though it is unclear if this effect is independent of and/or interacts with PTSD and depression.

methodThree overlapping samples of n = 582, 297, and 183 combat-deployed post-9/11 Veterans completed comprehensive assessments of executive functions, PTSD and depressive symptoms, and self-reported World Health Organization Disability Assessment Schedule-II (WHODAS II).

resultsPoorer performance on measures of inhibitory control (Delis-Kaplan Executive Functioning System Color-Word Interference-CWI Test and gradual-onset Continuous Performance Test-gradCPT), but not other executive functions, were significantly associated with greater disability on the WHODAS II (ρ's = -.13 and -.13, p = .002 and .026, respectively). CWI inhibitory control measures accounted for unique variance in disability after controlling for PTSD and depressive symptoms (R2 change = 0.02, p < .001). Further, CWI significantly moderated the effect of depressive symptoms on disability, such that better inhibitory control weakened the relationship between depression and disability.

conclusionsInhibitory control deficits are uniquely associated with increased disability in combat-deployed post-9/11 Veterans, and better inhibitory control abilities may serve as a protective factor for depressive symptoms leading to increased disability. KEY POINTS:

Indexed as

Stress Disorders, Post-TraumaticVeteransAdultDisability EvaluationExecutive FunctionHumansNeuropsychological TestsDepressionDisability/handicapsEveryday functioningExecutive functionsPosttraumatic stress disorder

Identifiers

PMID36781401
PMCPMC10456219
OpenAlexW4320489946

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.