SynthesisJournal of cachexia, sarcopenia and muscle2023
Sarcopenia is associated with a greater risk of polypharmacy and number of medications: a systematic review and meta-analysis.
Synthesis in Journal of cachexia, sarcopenia and muscle, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 5 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Evidence-based position paper on Physical and Rehabilitation Medicine (PRM) professional practice for persons with sarcopenia. The European PRM position (UEMS PRM Section).European journal of physical and rehabilitation medicine · 2026Pooled it
- Machine Learning and Deep Learning Models for Predicting Future Falls in Community-Dwelling Older Adults: Systematic Review and Meta-Analysis of Longitudinal Evidence.Journal of medical Internet research · 2026Pooled it
- How Pragmatic Are Sarcopenia Intervention Studies? A Systematic Review.Journal of cachexia, sarcopenia and muscle · 2026Pooled it
- Influence of Resistance Training Variables to Improve Muscle Mass Outcomes in Sarcopenia: A Systematic Review With Meta-Regressions.Journal of cachexia, sarcopenia and muscle · 2025Pooled it
- Sarcopenia is associated with a greater risk of polypharmacy and number of medications: a systematic review and meta-analysis.Journal of cachexia, sarcopenia and muscle · 2023Pooled it
- A young child formula with Limosilactobacillus reuteri and GOS modulates gut microbiome and enhances bone and muscle development: a randomized trial.Nature communications · 2025Trial
- Operationally Defined Sarcopenia Phenotype Among Older Egyptian Outpatients: A Descriptive Cross-Sectional Study.Nursing reports (Pavia, Italy) · 2026Article
- Exploring the Association of Polypharmacy and Depressive Symptoms with Sarcopenia in Older Adults.Journal of clinical medicine · 2026Article
- Relationship between polypharmacy, sarcopenia and drug classes in hospitalized older patients.Aging clinical and experimental research · 2026Article
- Association between Polypharmacy and Handgrip Strength in Older Patients undergoing Convalescent Rehabilitation: A Retrospective Cohort Study.Annals of geriatric medicine and research · 2026Observational
- Risk of Sarcopenia, Anxiety and Depression Among Healthcare Professionals in Disability Care Facilities.Journal of frailty, sarcopenia and falls · 2026Article
- Prevalence of sarcopenia and dynapenia among institutionalized older adults in the Lisbon region: associations with sex, nutritional status and body composition.BMC nutrition · 2026Article
- Life activities of elderly patients with operated nonfunctional pituitary adenoma.Frontiers in endocrinology · 2026Article
- Malnutrition-Sarcopenia Syndrome in older adults: Causes, consequences, and countermeasures.EXCLI journal · 2026Review
- Sarcopenia in older adults admitted to acute medical unit: a prospective observational study of feasibility and clinical outcomes.Frontiers in medicine · 2026Article
- Polypharmacy and Dynapenia in Older Adults Undergoing Rehabilitation After Fracture or Elective Orthopedic Surgery.Medicina (Kaunas, Lithuania) · 2025Article
- Polypharmacy and sarcopenia in patients on hemodialysis: results from the SARC-HD study.Aging clinical and experimental research · 2025Article
- Sarcopenia: how to determine and manage.Knee surgery & related research · 2025Review
- The Diagnosis and Treatment of Sarcopenia and Sarcopenic Obesity.Deutsches Arzteblatt international · 2025Review
- Effect of pre-hospital living setting on nutritional intake route upon discharge in older adults with aspiration pneumonia: a prospective cohort study.BMC geriatrics · 2025Article
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Authors and funding
15 authors at 11 institutions in 5 countries.
Funding
Abstract
Polypharmacy in older adults is associated with multiple negative consequences that may affect muscular function, independently from the presence of medical conditions. The aim of this systematic review and meta-analysis was to investigate the association of sarcopenia with polypharmacy and higher number of medications. A systematic literature search of observational studies using PubMed, Web of Science, Scopus and Cochrane Library databases was conducted from inception until June 2022. To determine if sarcopenia is associated with a higher risk of polypharmacy and increased number of medications, a meta-analysis using a random-effects model was used to calculate the pooled effects (CRD42022337539). Twenty-nine studies were included in the systematic review and meta-analysis. Sarcopenia was associated with a higher prevalence of polypharmacy (odds ratio [OR]: 1.65, 95% confidence interval [CI] [1.23, 2.20], I
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.