ArticleAmerican journal of respiratory and critical care medicine2023
PCSK6 and Survival in Idiopathic Pulmonary Fibrosis.
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Article in American journal of respiratory and critical care medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
9.3field-weighted citation impact, top 2% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Approach to the Evaluation and Management of Interstitial Lung Abnormalities: An Official American Thoracic Society Clinical Statement.American journal of respiratory and critical care medicine · 2025Guideline
- Reassessing the association of MUC5B with survival in idiopathic pulmonary fibrosis.Annals of human genetics · 2023Pooled it
- Multi-omics insights into the mechanisms and prognosis of IPF.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2026Review
- Next-Generation Sequencing in Pulmonary Fibrosis: Translational Promise and Current Clinical Limitations.Current issues in molecular biology · 2026Review
- Epithelial PCSK6 Promotes Proliferation and Decreases Collagen Deposition by Fibroblasts Potentially via MMP Activation.International journal of molecular sciences · 2026Article
- A trans-omics gene-smoking interaction study of lung cancer based on consortium data.American journal of respiratory and critical care medicine · 2026Article
- PCSK6 and clinical outcomes in the Pulmonary Fibrosis Foundation Patient Registry.Respiratory research · 2026Article
- Prospective study of fibrosis in the lung endpoints (PROFILE): characteristics of an incident cohort of patients with idiopathic pulmonary fibrosis.BMJ open respiratory research · 2026Observational
- Multi-omics approaches in idiopathic pulmonary fibrosis: from molecular mechanisms to therapeutic targets and precision medicine.Frontiers in pharmacology · 2026Review
- Smoking exposures and mortality risk in individuals with idiopathic pulmonary fibrosis: a UK Biobank cohort study.Frontiers in public health · 2026Article
- Genetic Familial Interstitial Lung Disease.Clinics in chest medicine · 2025Review
- The role of theERJ open research · 2025Article
- Rare variants and survival of patients with idiopathic pulmonary fibrosis: analysis of a multicentre, observational cohort study with independent validation.The Lancet. Respiratory medicine · 2025Observational
- Review
- Genetic variation reveals the therapeutic potential of BRSK2 in idiopathic pulmonary fibrosis.BMC medicine · 2025Article
- An Overview of the Role of Genetic factors in Idiopathic Pulmonary Fibrosis: Insights from Epidemiology to Prognosis.International journal of medical sciences · 2025Review
- Imperfect wound healing sets the stage for chronic diseases.Science (New York, N.Y.) · 2024Review
- Biomarker-defined endotypes of pulmonary fibrosis.The Lancet. Respiratory medicine · 2024Article
- Transcriptome-Wide Association Study of Idiopathic Pulmonary Fibrosis Survival IdentifiesAmerican journal of respiratory and critical care medicine · 2024Article
- Genetics and Genomics of Pulmonary Fibrosis: Charting the Molecular Landscape and Shaping Precision Medicine.American journal of respiratory and critical care medicine · 2024Review
Corrections and comments
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Authors and funding
48 authors at 13 institutions in 3 countries.
Justin M OldhamDivision of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, Michigan.ORCID 0000-0003-4957-8869
Richard J AllenDepartment of Health Sciences, University of Leicester, Leicester, United Kingdom.
Jose M Lorenzo-SalazarGenomics Division, Instituto Tecnológico y de Energías Renovables, Santa Cruz de Tenerife, Spain.
Philip L MolyneauxNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Shwu-Fan MaDivision of Pulmonary and Critical Care Medicine and.
Chitra JosephDivision of Respiratory Medicine and.
John S KimDivision of Pulmonary and Critical Care Medicine and.
Beatriz Guillen-GuioDepartment of Health Sciences, University of Leicester, Leicester, United Kingdom.
Tamara Hernández-BeeftinkResearch Unit, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain.
Jonathan A KropskiDivision of Pulmonary and Critical Care Medicine, Vanderbilt University, Nashville, Tennessee.
Yong HuangDivision of Pulmonary and Critical Care Medicine and.
Cathryn T LeeSection of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, Illinois.
Ayodeji AdegunsoyeSection of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, Illinois.
Janelle Vu PugashettiDivision of Pulmonary, Critical Care and Sleep Medicine, University of California, Davis, Davis, California.ORCID 0000-0002-8889-2757
Angela L LinderholmDivision of Pulmonary, Critical Care and Sleep Medicine, University of California, Davis, Davis, California.
Vivian VoDivision of Pulmonary, Critical Care and Sleep Medicine, University of California, Davis, Davis, California.
Mary E StrekSection of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, Illinois.
Jonathan JouDepartment of Surgery, College of Medicine, University of Illinois, Peoria, Illinois.
Adrian Muñoz-BarreraGenomics Division, Instituto Tecnológico y de Energías Renovables, Santa Cruz de Tenerife, Spain.
Luis A Rubio-RodriguezGenomics Division, Instituto Tecnológico y de Energías Renovables, Santa Cruz de Tenerife, Spain.
Richard HubbardDivision of Epidemiology and Public Health, University of Nottingham, Nottingham, United Kingdom.
Nik HiraniMedical Research Council Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom.
Moira K B WhyteMedical Research Council Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom.
Simon HartRespiratory Research Group, Hull York Medical School, Castle Hill Hospital, Cottingham, United Kingdom.
Andrew G NicholsonNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Lisa LancasterDivision of Pulmonary and Critical Care Medicine, Vanderbilt University, Nashville, Tennessee.
Helen ParfreyCambridge Interstitial Lung Disease Service, Royal Papworth Hospital, Cambridge, United Kingdom.
Doris RasslCambridge Interstitial Lung Disease Service, Royal Papworth Hospital, Cambridge, United Kingdom.
William WallaceMedical Research Council Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom.
Eleanor ValenziDivision of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.ORCID 0000-0003-0656-6542
Yingze ZhangDivision of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Josyf MychaleckyjCenter for Public Health Genomics, University of Virginia, Charlottesville, Virginia.
Amy StockwellGenentech Inc., San Francisco, California.
Naftali KaminskiSection of Pulmonary, Critical Care and Sleep Medicine, School of Medicine, Yale University, New Haven, Connecticut.ORCID 0000-0001-5917-4601
Paul J WoltersDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, San Francisco, California.
Maria Molina-MolinaServei de Pneumologia, Laboratori de Pneumologia Experimental, Instituto de Investigación Biomédica de Bellvitge, Campus de Bellvitge, Universitat de Barcelona, Barcelona, Spain.
Nicholas E BanovichTranslational Genomics Research Institute, Phoenix, Arizona.
William A FahyDiscovery Medicine, GlaxoSmithKline, Stevenage, United Kingdom.
Fernando J MartinezWeill Cornell Medical Center, New York, New York.
Ian P HallDivision of Respiratory Medicine and.ORCID 0000-0001-9933-3216
Martin D TobinDepartment of Health Sciences, University of Leicester, Leicester, United Kingdom.
Toby M MaherNational Heart and Lung Institute, Imperial College London, London, United Kingdom.ORCID 0000-0001-7192-9149
Timothy S BlackwellDivision of Pulmonary and Critical Care Medicine, Vanderbilt University, Nashville, Tennessee.ORCID 0000-0002-0337-7052
Brian L YaspanGenentech Inc., San Francisco, California.
R Gisli JenkinsNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Carlos FloresGenomics Division, Instituto Tecnológico y de Energías Renovables, Santa Cruz de Tenerife, Spain.
Louise V WainDepartment of Health Sciences, University of Leicester, Leicester, United Kingdom.
Imre NothDivision of Pulmonary and Critical Care Medicine and.
University of Michigan · USUniversity of Leicester · GBGuy's and St Thomas' NHS Foundation Trust · GBVanderbilt University · USNottingham University Hospitals NHS Trust · GBUniversity of Pittsburgh · USUniversity of Ulster · GBCornell University · USGlaxoSmithKline (United Kingdom) · GBIllinois College · USTranslational Genomics Research Institute · USUniversity of California, San Francisco · USUniversity of Southern California · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MMechanisms of Familial Pulmonary FibrosisP01HL092870 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BLACKWELL, TIMOTHY S. · 2010 to 2020
$21.6MPULMONARY CELLULAR AND MOLECULAR BIOLOGY TRAININGT32HL007749 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Robert Pickett Dickson · 1993 to 2026
$19.9MRESEARCH TRAINING IN RESPIRATORY BIOLOGYT32HL007605 · NHLBI · UNIVERSITY OF CHICAGO · PI Yun Fang, Gokhan M. Mutlu · 1985 to 2026
$18.1M1/2 Prospective tReatment EffiCacy in IPF uSlng genOtype for Nac Selection (PRECISIONS) trial and Molecular Endophenotyping in Idiopathic Pulmonary Fibrosis and Interstitial Lung Diseases studyUH3HL145266 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI MARTINEZ, FERNANDO J, NOTH, IMRE · 2021 to 2025
$11.6MSpatiotemporal genomic regulation of disease initiation and progression in pulmonary fibrosisR01HL145372 · NHLBI · TRANSLATIONAL GENOMICS RESEARCH INST · PI Nicholas Eli Banovich, Jonathan Andrew Kropski · 2019 to 2026
$6.0MArchitectural structure and regulation of TOLLIP in IPFR01HL130796 · NHLBI · UNIVERSITY OF VIRGINIA · PI NOTH, IMRE · 2016 to 2019
$3.1M1/2 Prospective tReatment EffiCacy in IPF uSlng genOtype for Nac Selection (PRECISIONS) trial and Molecular Endophenotyping in Idiopathic Pulmonary Fibrosis and Interstitial Lung Diseases studyUG3HL145266 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI MARTINEZ, FERNANDO J, NOTH, IMRE · 2019 to 2019
$977kElucidating the Genomic Determinants of Outcomes in Idiopathic Pulmonary FibrosisK23HL138190 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OLDHAM, JUSTIN M · 2017 to 2021
$914kRole of polyunsaturated fatty acids in pulmonary fibrosisK23HL150301 · NHLBI · UNIVERSITY OF VIRGINIA · PI KIM, JOHN S · 2021 to 2025
$858kImproving Pulmonary Fibrosis Classification with Genomics Informed Phenotypic ClustersK23HL146942 · NHLBI · UNIVERSITY OF CHICAGO · PI ADEGUNSOYE, AYODEJI · 2020 to 2024
$810kDerivation and validation of a clinical-molecular signature to predict fibrotic progression and treatment response in patients with autoimmune interstitial lung diseaseR56HL158935 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI OLDHAM, JUSTIN M · 2021 to 2021
$400kBLRD VA I01 BX002378Department of Health CS-2013-13-017Department of Health NIHR201371Department of Health RP-2017-08-ST2-014HSRD VA CDA 13-017Medical Research Council G0901226Medical Research Council MR/V00235X/1NCATS NIH HHS UL1 TR001863NHLBI NIH HHS K23 HL138190NHLBI NIH HHS K23 HL146942NHLBI NIH HHS K23 HL150301NHLBI NIH HHS P01 HL092870NHLBI NIH HHS R01 HL130796NHLBI NIH HHS R01 HL145372NHLBI NIH HHS R56 HL158935NHLBI NIH HHS T32 HL007605NHLBI NIH HHS T32 HL007749NHLBI NIH HHS UG3 HL145266NHLBI NIH HHS UH3 HL145266Wellcome Trust 221680/Z/20/ZWellcome Trust 225221Wellcome Trust WT202849/Z/16/Z
Abstract
PubMed holds no abstract for this paper.
Indexed as
Genome-Wide Association StudyIdiopathic Pulmonary FibrosisEuropeHumansLungProportional Hazards ModelsProprotein ConvertasesSerine EndopeptidasesPCSK6 protein, humanProprotein ConvertasesSerine Endopeptidasesgenome-wide association studygenomicsIPFPCSK6 proteinsurvival
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.