Evidence map›Paper›PMID 36780314›Full record

ArticleBiomacromolecules2023

Glycopolymers Mediate Suicide Gene Therapy in ASGPR-Expressing Hepatocellular Carcinoma Cells in Tandem with Docetaxel.

Daniela Santo, Rosemeyre A Cordeiro, Patrícia V Mendonça, Arménio C Serra, Jorge F J Coelho, Henrique Faneca

Open access · hybridFull text read
In one paragraph

Article in Biomacromolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Daniela SantoCenter for Neuroscience and Cell Biology, University of Coimbra, Coimbra 3004-504, Portugal.
Rosemeyre A CordeiroCenter for Neuroscience and Cell Biology, University of Coimbra, Coimbra 3004-504, Portugal.ORCID 0000-0001-7785-5275
Patrícia V MendonçaCentre for Mechanical Engineering, Materials and Processes, Department of Chemical Engineering, University of Coimbra, Coimbra 3030-790, Portugal.
Arménio C SerraCentre for Mechanical Engineering, Materials and Processes, Department of Chemical Engineering, University of Coimbra, Coimbra 3030-790, Portugal.ORCID 0000-0001-8664-2757
Jorge F J CoelhoCentre for Mechanical Engineering, Materials and Processes, Department of Chemical Engineering, University of Coimbra, Coimbra 3030-790, Portugal.ORCID 0000-0001-9351-1704
Henrique FanecaCenter for Neuroscience and Cell Biology, University of Coimbra, Coimbra 3004-504, Portugal.ORCID 0000-0001-5554-7829
University of Coimbra · PTInstituto Pedro Nunes · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cationic glycopolymers stand out as gene delivery nanosystems due to their inherent biocompatibility and high binding affinity to the asialoglycoprotein receptor (ASGPR), a target receptor overexpressed in hepatocellular carcinoma (HCC) cells. However, their synthesis procedure remains laborious and complex, with problems of solubilization and the need for protection/deprotection steps. Here, a mini-library of well-defined poly(2-aminoethyl methacrylate hydrochloride-

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsAsialoglycoprotein ReceptorCell Line, TumorDocetaxelGenetic TherapyHumansAsialoglycoprotein ReceptorDocetaxel

Identifiers

PMID36780314
PMCPMC10015461
OpenAlexW4320484695

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read37
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.