ArticleNeurourology and urodynamics2023
The biopsychosocial impacts of anxiety on overactive bladder in women.
Article in Neurourology and urodynamics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 5 citations in OpenAlex.
- The Afferent Threshold Hypothesis: A Unified Neural Framework for Functional Bladder Capacity and Nocturia.International neurourology journal · 2026Article
- Navigating the challenges of overactive bladder management in women.World journal of urology · 2026Review
- Social Vulnerability Is Associated With Worse Urinary Incontinence and Quality of Life in Women.Urology · 2025Article
- Association between novel anthropometric indices and overactive bladder: a population-based study.Frontiers in nutrition · 2025Article
- The Psychosocial Impact of Urinary Dysfunction.Urology research & practice · 2024Review
- Benzodiazepines use and dependence in female patients with overactive bladder symptoms - prevalence and clinical correlations.Central European journal of urology · 2024Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
aimsLinks between emotional state and the bladder have long been recognized, as psychological comorbidity is a common feature of overactive bladder (OAB). However, how psychological factors might contribute to the development and severity of OAB remains unclear. Therefore, we sought to examine the effect of anxiety on OAB with a specific focus on bladder hypersensitivity.
methodsIn a sample of 120 adult women with OAB, we compared those with at least mild anxiety (PROMIS Anxiety score ≥55) to those with lower anxiety. Analyses focused on patient-reported questionnaires assessing urinary symptom severity and quality of life, psychological stress symptoms, general somatic symptoms, and results of quantitative sensory testing (QST), including temporal summation to heat pain (TSP). TSP was used to index elevated C-fiber responsiveness (i.e., central sensitization).
resultsThirty-six (30%) women had at least mild anxiety. While there were no group differences for urinary symptom severity, more anxious women reported worse OAB-specific quality of life, greater psychological stress burden, higher stress reactivity, and greater somatic symptoms. On QST, there were no differences between anxiety groups for pain threshold (43.6 ± 3.1°C vs. 44.0 ± 3.1°C, p = 0.6) and tolerance (47.3 ± 1.5°C vs. 47.4 ± 1.6°C, p = 0.7). However, those with anxiety had significantly higher TSP than those without anxiety (6.0 ± 4.8 vs. 3.7 ± 3.9, p = 0.006), indicating greater central sensitization.
conclusionsWomen with OAB and at least mild anxiety symptoms reported greater psychosocial burdens (i.e., psychological stress, stress reactivity, OAB-specific QOL) and somatic symptom severity and demonstrated greater central sensitization on QST than those without anxiety. These findings support the hypothesis that anxiety and psychological stress impact hypersensitivity mechanisms that may underlie and contribute to OAB, although further research is needed to better understand how and to what extent.
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