ArticleeLife2023
Csf1 from marrow adipogenic precursors is required for osteoclast formation and hematopoiesis in bone.
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Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30citing papers in PubMed
6.8field-weighted citation impact, top 3% of its field
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Who cites it
30 citing papers in PubMed, 44 citations in OpenAlex.
- Not just fillers: the emerging role of bone marrow adipocytes in bone and bone marrow homeostasis.Biology open · 2026Review
- Youthfulness of marrow AdipoqBone research · 2026Article
- CSF1R+ Macrophages and Osteoclasts Are Essential for Limb Bone Development During Embryogenesis.Journal of developmental biology · 2026Article
- Depletion and replacement of tissue-resident macrophages in mice with germ-line deletion of a conserved enhancer in the Csf1r locus.Development (Cambridge, England) · 2026Article
- Cell signaling and transcriptional regulation of osteoclast lineage commitment, differentiation, bone resorption and diseases.Cell discovery · 2026Review
- Identification and Mechanisms of Osteocyte Subsets Involved in the Pathological Progression of Osteoporosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Bone marrow adipoq-lineage cells in regulating the bone and marrow microenvironment: identities, functions, and mechanisms.Frontiers in endocrinology · 2026Review
- From Development, Disease, and Decline: A Review of What Defines an Osteoclast Progenitor.International journal of molecular sciences · 2025Review
- Macrophage-derived amphiregulin induces myofibroblast transition in adipogenic lineage precursors near Staphylococcus aureus abscess in bone marrow.Nature communications · 2025Article
- Marrow adipogenic lineage precursors (MALPs) facilitate bone marrow recovery after chemotherapy.Bone · 2025Article
- Bone marrow adipogenic lineage precursors are the major regulator of bone resorption in adult mice.Bone research · 2025Article
- Skeletal stem and progenitor cells in bone physiology, ageing and disease.Nature reviews. Endocrinology · 2025Review
- Single-Cell Landscape of the Cochlea Revealed Cell-Type-Specific Diversification inBiomolecules · 2025Article
- Deep imaging of LepRBone research · 2025Article
- Damage of the Bone Marrow Stromal Precursors in Patients with Acute Leukemia at the Onset of the Disease and During Treatment.International journal of molecular sciences · 2024Article
- Review
- FOXO1-mTOR pathway in vascular pericyte regulates the formation of type H vessels to control bone metabolism.Journal of orthopaedic translation · 2024Article
- Bone marrow adipogenic lineage precursors are the major regulator of bone resorption in adult mice.Research square · 2024Article
- Metabolic regulation of skeletal cell fate and function.Nature reviews. Endocrinology · 2024Review
- Function and Regulation of Bone Marrow Adipose Tissue in Health and Disease: State of the Field and Clinical Considerations.Comprehensive Physiology · 2024Review
Corrections and comments
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Authors and funding
19 authors at 5 institutions in 2 countries.
Leilei ZhongDepartment of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Jiawei LuDepartment of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Jiankang FangDepartment of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Lutian YaoDepartment of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Wei YuDepartment of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Tao GuiDepartment of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Michael DuffyDepartment of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Nicholas HoldreithDivision of Hematology, Children's Hospital of Philadelphia, Philadelphia, United States.
Catherine A BautistaDepartment of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Xiaobin HuangDepartment of Oral and Maxillofacial Surgery/Pharmacology, School of Dental Medicine, University of Pennsylvania, Philadelphia, United States.
Shovik BandyopadhyayGraduate Group in Cell and Molecular Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Kai TanDepartment of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Chider ChenDepartment of Oral and Maxillofacial Surgery/Pharmacology, School of Dental Medicine, University of Pennsylvania, Philadelphia, United States.ORCID 0000-0003-2899-1208
Yongwon ChoiDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Jean X JiangDepartment of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, United States.ORCID 0000-0002-2185-5716
Shuying YangDepartment of Basic and Translational Sciences, School of Dental Medicine, University of Pennsylvania, Philadelphia, United States.ORCID 0000-0002-7126-6901
Wei TongDivision of Hematology, Children's Hospital of Philadelphia, Philadelphia, United States.
Nathanial DymentDepartment of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.ORCID 0000-0001-8708-112X
Ling QinDepartment of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.ORCID 0000-0002-2582-0078
University of Pennsylvania · USChildren's Hospital of Philadelphia · USFirst Affiliated Hospital of Jinan University · CNHuazhong University of Science and Technology · CNThe University of Texas Health Science Center at San Antonio · US
Funding
TRANSGENIC COREP30AG013319 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI JAMES FLOYD NELSON · 1995 to 2026
$30.6MHEMATOLOGY CLINICAL RESEARCH TRAINING PROGRAMT32HL007439 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI LAWRENCE F BRASS, PETER S KLEIN · 1985 to 2026
$17.1MOverall: Resource-based Center for Musculoskeletal Disorders Research (Overall Application)P30AR069619 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI LOUIS J SOSLOWSKY · 2016 to 2026
$9.1MRegulation of Ribosome Biogenesis in Hematopoietic Stem CellsR01DK127738 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI TONG, WEI · 2020 to 2024
$3.0MNovel Regulation of Oncogenic NRAS Signaling in Myeloid MalignanciesR01CA271523 · NCI · CHILDREN'S HOSP OF PHILADELPHIA · PI Wei Tong · 2022 to 2026
$2.7MControl of bone physiology by a novel type of adipose cellsR01AG069401 · NIA · UNIVERSITY OF PENNSYLVANIA · PI QIN, LING · 2021 to 2025
$2.3MCSF-1 Gene Expression in Osteoclast BiologyR01AG045040 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI JIANG, JEAN X · 2013 to 2017
$1.5MDefining the Tendon Lineage to Improve Tissue Engineering StrategiesR00AR067283 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI DYMENT, NATHANIEL A. · 2017 to 2019
$719kFat and synovial tissue remodeling in joint osteoarthritisR21AR078650 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI QIN, LING, SEALE, PATRICK · 2021 to 2021
$393kNCI NIH HHS R01 CA271523NHLBI NIH HHS T32 HL007439NHLBI NIH HHS T32HL007439NIAMS NIH HHS P30 AR069619NIAMS NIH HHS R00 AR067283NIAMS NIH HHS R00AR067283NIAMS NIH HHS R21 AR078650NIAMS NIH HHS R21AR078650NIA NIH HHS P30 AG013319NIA NIH HHS R01 AG045040NIA NIH HHS R01AG045040NIA NIH HHS R01 AG069401NIA NIH HHS R01AG069401NIDDK NIH HHS R01 DK127738
Abstract
Colony-stimulating factor 1 (Csf1) is an essential growth factor for osteoclast progenitors and an important regulator for bone resorption. It remains elusive which mesenchymal cells synthesize
Indexed as
Bone MarrowOsteoclastsAnimalsBone and BonesHematopoiesisMacrophage Colony-Stimulating FactorMiceMacrophage Colony-Stimulating Factorbonecell biologyCsf1hematopoiesismarrow adipogenic lineage precursorsmedicinemouseosteoclasts
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measurements read62
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.