Evidence map›Paper›PMID 36779761›Full record

ArticleJournal of virology2023

Deletion of the s2m RNA Structure in the Avian Coronavirus Infectious Bronchitis Virus and Human Astrovirus Results in Sequence Insertions.

Sarah Keep, Giulia Dowgier, Valeria Lulla, Paul Britton, Michael Oade, Graham Freimanis, Chandana Tennakoon, Christine Monceyron Jonassen, Torstein Tengs, Erica Bickerton

Open access · hybridAbstract read
In one paragraph

Article in Journal of virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

  1. Molecular detection of paramyxovirus and coronavirus in fecal samples of shorebirds from Southern Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Sarah Keep *The Pirbright Institute, Woking, United Kingdom.ORCID 0000-0001-9583-630X
Giulia Dowgier *The Francis Crick Institute, London, United Kingdom.
Valeria LullaDepartment of Pathology, University of Cambridge, Addenbrookes Hospital, Cambridge, United Kingdom.ORCID 0000-0002-6605-0727
Paul BrittonThe Pirbright Institute, Woking, United Kingdom.
Michael OadeDepartment of Pathology, University of Cambridge, Addenbrookes Hospital, Cambridge, United Kingdom.
Graham FreimanisThe Pirbright Institute, Woking, United Kingdom.
Chandana TennakoonThe Pirbright Institute, Woking, United Kingdom.
Christine Monceyron JonassenDepartment of Virology, Norwegian Institute of Public Health, Oslo, Norway.
Torstein TengsDepartment of Breeding and Genetics, Nofima, Ås, Norway.
Erica BickertonThe Pirbright Institute, Woking, United Kingdom.ORCID 0000-0002-4012-1283
The Pirbright Institute · GBNofima · NONorwegian Institute of Public Health · NOPrinceton University · USThe Francis Crick Institute · GBUniversity of Cambridge · GB

Funding

Biotechnology and Biological Sciences Research Council BBS/E/I/00007034Biotechnology and Biological Sciences Research Council BBS/E/I/00007037Biotechnology and Biological Sciences Research Council BBS/E/I/00007038Biotechnology and Biological Sciences Research Council BBS/E/I/00007039Biotechnology and Biological Sciences Research Council BBS/E/I/COV07001Wellcome Trust 220620
6 · The paper itself

Abstract

Coronaviruses infect a wide variety of host species, resulting in a range of diseases in both humans and animals. The coronavirus genome consists of a large positive-sense single-stranded molecule of RNA containing many RNA structures. One structure, denoted s2m and consisting of 41 nucleotides, is located within the 3' untranslated region (3' UTR) and is shared between some coronavirus species, including infectious bronchitis virus (IBV), severe acute respiratory syndrome coronavirus (SARS-CoV), and SARS-CoV-2, as well as other pathogens, including human astrovirus. Using a reverse genetic system to generate recombinant viruses, we investigated the requirement of the s2m structure in the replication of IBV, a globally distributed economically important

Indexed as

Infectious bronchitis virusMamastrovirusMutagenesis, Insertional3' Untranslated RegionsAnimalsChickensHumansPoultry DiseasesRNA StabilityRNA, ViralSequence DeletionVirus Replication3' Untranslated RegionsRNA, Viralcoronavirushuman astrovirusinfectious bronchitis virusRNA structures2m

Identifiers

PMID36779761
PMCPMC10062133
OpenAlexW4320485687

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.