Evidence map›Paper›PMID 36779722›Full record

ArticlemBio2023

Capsular Polysaccharide Is Essential for the Virulence of the Antimicrobial-Resistant Pathogen Enterobacter hormaechei.

Amelia St John, Andrew I Perault, Sabrina I Giacometti, Alexis G Sommerfield, Ashley L DuMont, Keenan A Lacey, Xuhui Zheng, Julia Sproch, Chris Petzold, Kristen Dancel-Manning and 10 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Fast and accurateMicrobial genomics · 2025
    Article
  5. Whole Genome Sequencing of Carbapenem-ResistantIndian journal of microbiology · 2025
    Article
  6. Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Article
  8. Genomic Study of High-Risk Clones ofAntibiotics (Basel, Switzerland) · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Genomic characterization ofFrontiers in cellular and infection microbiology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 1 country.

Amelia St John *Department of Microbiology, New York University Grossman School of Medicine, New York, New York, USA.
Andrew I Perault *Department of Microbiology, New York University Grossman School of Medicine, New York, New York, USA.
Sabrina I GiacomettiDepartment of Cell Biology, New York University Grossman School of Medicine, New York, New York, USA.
Alexis G SommerfieldDepartment of Microbiology, New York University Grossman School of Medicine, New York, New York, USA.
Ashley L DuMontDepartment of Microbiology, New York University Grossman School of Medicine, New York, New York, USA.
Keenan A LaceyDepartment of Microbiology, New York University Grossman School of Medicine, New York, New York, USA.
Xuhui ZhengDepartment of Microbiology, New York University Grossman School of Medicine, New York, New York, USA.ORCID 0000-0002-3989-7236
Julia SprochDepartment of Microbiology, New York University Grossman School of Medicine, New York, New York, USA.
Chris PetzoldMicroscopy Laboratory, Division of Advanced Research Technologies, New York University Langone Health, New York, New York, USA.
Kristen Dancel-ManningMicroscopy Laboratory, Division of Advanced Research Technologies, New York University Langone Health, New York, New York, USA.
Sandra GonzalezDepartment of Microbiology, New York University Grossman School of Medicine, New York, New York, USA.
Medini AnnavajhalaDepartment of Medicine, Division of Infectious Diseases, Columbia University Medical Center, New York, New York, USA.ORCID 0000-0002-9229-8849
Colleen BeckfordDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Nathalie ZeitouniIcahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Feng-Xia LiangMicroscopy Laboratory, Division of Advanced Research Technologies, New York University Langone Health, New York, New York, USA.
Harm van BakelDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Bo ShopsinDepartment of Microbiology, New York University Grossman School of Medicine, New York, New York, USA.
Anne-Catrin UhlemannDepartment of Medicine, Division of Infectious Diseases, Columbia University Medical Center, New York, New York, USA.
Alejandro PirontiDepartment of Microbiology, New York University Grossman School of Medicine, New York, New York, USA.
Victor J TorresDepartment of Microbiology, New York University Grossman School of Medicine, New York, New York, USA.ORCID 0000-0002-7126-0489
New York University · USIcahn School of Medicine at Mount Sinai · USNYU Langone Health · USColumbia University Irving Medical Center · US

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ANIRBAN MAITRA · 1985 to 2026
$83.1M
Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4M
INFECTIOUS DISEASES &BASIC MICROBIOLOGICAL MECHANISMST32AI007180 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI WEISER, JEFFREY NEAL · 1985 to 2022
$8.9M
COVID and Translational Science supercomputer (CATS)S10OD030463 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2021 to 2021
$2.0M
Big Omics Data Engine 2 SupercomputerS10OD026880 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2019 to 2019
$2.0M
NCATS NIH HHS UL1 TR004419NCI NIH HHS P30 CA016087NIAID NIH HHS T32 AI007180NIH HHS S10 OD026880NIH HHS S10 OD030463
6 · The paper itself

Abstract

Nosocomial infections caused by multidrug-resistant (MDR) Enterobacter cloacae complex (ECC) pathogens are on the rise. However, the virulence strategies employed by these pathogens remain elusive. Here, we study the interaction of ECC clinical isolates with human serum to define how this pathogen evades the antimicrobial action of complement, one of the first lines of host-mediated immune defense. We identified a small number of serum-sensitive strains, including Enterobacter hormaechei strain NR3055, which we exploited for the

Indexed as

EnterobacterEnterobacteriaceae InfectionsAnimalsAnti-Bacterial AgentsHumansMiceMicrobial Sensitivity TestsPolysaccharidesVirulenceAnti-Bacterial AgentsPolysaccharidesantimicrobial resistancecapsulecomplementEnterobacterpathogenesisserumserum resistance

Identifiers

PMID36779722
PMCPMC10127600
OpenAlexW4320490738

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.