Evidence map›Paper›PMID 36779623›Full record

ArticleJournal of visualized experiments : JoVE2023

The Superficial Inferior Epigastric Artery Axial Flap to Study Ischemic Preconditioning Effects in a Rat Model.

Yanis Berkane, Austin Alana Shamlou, Jose Reyes, Hyshem H Lancia, Irina Filz von Reiterdank, Nicolas Bertheuil, Basak E Uygun, Korkut Uygun, William G Austen, Curtis L Cetrulo and 2 more

Abstract readVideo-Audio Media
In one paragraph

Article in Journal of visualized experiments : JoVE, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yanis Berkane *Vascularized Composite Allotransplantation Laboratory, Massachusetts General Hospital; Harvard Medical School; Department of Plastic, Reconstructive and Aesthetic Surgery, Rennes University Hospital Center (CHU de Rennes), University of Rennes 1; Shriners Children's Boston.
Austin Alana Shamlou *Vascularized Composite Allotransplantation Laboratory, Massachusetts General Hospital; Harvard Medical School; Plastic Surgery Research Laboratory, Massachusetts General Hospital; Shriners Children's Boston.
Jose ReyesVascularized Composite Allotransplantation Laboratory, Massachusetts General Hospital; Harvard Medical School.
Hyshem H LanciaVascularized Composite Allotransplantation Laboratory, Massachusetts General Hospital; Harvard Medical School; Shriners Children's Boston.
Irina Filz von ReiterdankVascularized Composite Allotransplantation Laboratory, Massachusetts General Hospital; Harvard Medical School; Shriners Children's Boston; Center for Engineering in Medicine and Surgery, Massachusetts General Hospital; Department of Plastic Surgery and Hand Surgery, University Medical Center Utrecht.
Nicolas BertheuilDepartment of Plastic, Reconstructive and Aesthetic Surgery, Rennes University Hospital Center (CHU de Rennes), University of Rennes 1.
Basak E UygunHarvard Medical School; Shriners Children's Boston; Center for Engineering in Medicine and Surgery, Massachusetts General Hospital.
Korkut UygunVascularized Composite Allotransplantation Laboratory, Massachusetts General Hospital; Harvard Medical School; Shriners Children's Boston; Center for Engineering in Medicine and Surgery, Massachusetts General Hospital.
William G AustenHarvard Medical School; Plastic Surgery Research Laboratory, Massachusetts General Hospital.
Curtis L CetruloVascularized Composite Allotransplantation Laboratory, Massachusetts General Hospital; Harvard Medical School; Plastic Surgery Research Laboratory, Massachusetts General Hospital; Shriners Children's Boston.
Mark A RandolphVascularized Composite Allotransplantation Laboratory, Massachusetts General Hospital; Harvard Medical School; Plastic Surgery Research Laboratory, Massachusetts General Hospital; Shriners Children's Boston.
Alexandre G LellouchVascularized Composite Allotransplantation Laboratory, Massachusetts General Hospital; Harvard Medical School; Shriners Children's Boston; Center for Engineering in Medicine and Surgery, Massachusetts General Hospital; Department of Plastic, Reconstructive, and Aesthetic Surgery, Groupe Almaviva Santé, Clinique de l'Alma; alellouch@mgh.harvard.edu.

Funding

Development of engineered fasciocutaneous skin flapsR01AR082825 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI Basak Elif Uygun · 2023 to 2026
$1.4M
NIAMS NIH HHS R01 AR082825
6 · The paper itself

Abstract

Fasciocutaneous flaps (FCF) have become the gold standard for complex defect reconstruction in plastic and reconstructive surgery. This muscle-sparing technique allows transferring vascularized tissues to cover any large defect. FCF can be used as pedicled flaps or as free flaps; however, in the literature, failure rates for pedicled FCF and free FCF are above 5%, leaving room for improvement for these techniques and further knowledge expansion in this area. Ischemic preconditioning (I.P.) has been widely studied, but the mechanisms and the optimization of the I.P. regimen are yet to be determined. This phenomenon is indeed poorly explored in plastic and reconstructive surgery. Here, a surgical model is presented to study the I.P. regimen in a rat axial fasciocutaneous flap model, describing how to safely and reliably assess the effects of I.P. on flap survival. This article describes the complete surgical procedure, including suggestions to improve the reliability of this model. The objective is to provide researchers with a reproducible and reliable model to test various ischemic preconditioning regimens and assess their effects on flap survivability.

Indexed as

Free Tissue FlapsIschemic PreconditioningAnimalsEpigastric ArteriesRatsReproducibility of Results

Identifiers

PMID36779623
PMCPMC10910865

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.