Evidence map›Paper›PMID 36779618›Full record

ArticleCancer medicine2023

Characteristics and outcomes of gallbladder cancer patients at the Tata Medical Center, Kolkata 2017-2019.

Anindita Dutta, Tushar Mungle, Nandita Chowdhury, Pritha Banerjee, Anisha Gehani, Saugata Sen, Mohandas Mallath, Paromita Roy, Shekhar Krishnan, Sandip Ganguly and 3 more

Open access · goldAbstract read
In one paragraph

Article in Cancer medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Gallbladder cholangiocyte organoids.Biology of the cell · 2025
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Anindita DuttaCell Biology, Tata Translational Cancer Research Centre, Kolkata, India.
Tushar MungleClinical Research Unit, Tata Translational Cancer Research Centre, Kolkata, India.ORCID 0000-0002-2109-3248
Nandita ChowdhuryCell Biology, Tata Translational Cancer Research Centre, Kolkata, India.
Pritha BanerjeeClinical Research Unit, Tata Translational Cancer Research Centre, Kolkata, India.
Anisha GehaniDepartment of Radiology, Tata Medical Center, Kolkata, India.
Saugata SenDepartment of Radiology, Tata Medical Center, Kolkata, India.
Mohandas MallathDepartment of Digestive Diseases, Tata Medical Center, Kolkata, India.
Paromita RoyDepartment of Histopathology, Tata Medical Center, Kolkata, India.
Shekhar KrishnanDivision of Cancer Sciences, University of Manchester, Manchester, UK.ORCID 0000-0002-6769-3847
Sandip GangulyDepartment of Medical Oncology, Tata Medical Center, Kolkata, India.
Sudeep BanerjeeDepartment of Gastrointestinal and Hepatobiliary Surgery, Tata Medical Center, Kolkata, India.
Manas RoyDepartment of Gastrointestinal and Hepatobiliary Surgery, Tata Medical Center, Kolkata, India.
Vaskar SahaCell Biology, Tata Translational Cancer Research Centre, Kolkata, India.ORCID 0000-0002-2916-9649
Tata Medical Center · INUniversity of Manchester · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

backgroundThe north and north-eastern regions of India have among the highest incidence of gallbladder cancer (GBC) in the world. We report the clinicopathological charateristics and outcome of GBC patients in India.

methodsElectronic medical records of patients diagnosed with GBC at Tata Medical Center, Kolkata between 2017 and 2019 were analyzed.

resultsThere were 698 cases of confirmed GBC with a median age of 58 (IQR: 50-65) years and female:male ratio of 1.96. At presentation, 91% (496/544) had stage III/IV disease and 30% (189/640) had incidental GBC. The 2-year overall survival (OS) was 100% (95% CI: 100-100); 61% (95% CI: 45-83); 30% (95% CI: 21-43); and 9% (95% CI: 6-13) for stages I-IV, respectively (p = <0.0001).   For all patients, the 2-year OS in patients who had a radical cholecystectomy followed by adjuvant therapy (N = 36) was 50% (95% CI: 39-64), compared to 29% (95% CI: 22-38) for those who had a simple cholecystectomy and/or chemotherapy (N = 265) and 9% (95% CI: 6-14) in patients who were palliated (N = 107) (p = <0.0001).

conclusionThe combined surgical/chemotherapy approach for patients with stage II GBC showed the best outcomes. Early detection of GBC remains problematic with the majority of patients presenting with stage III-IV and who have a median survival of 9.1 months. Our data suggests that the tumor is chemoresponsive and multi-center collaborative clinical trials to identify alternative therapies are urgently required.

Indexed as

Carcinoma in SituGallbladder NeoplasmsAgedCholecystectomyCombined Modality TherapyFemaleHospitalsHumansMaleMiddle AgedNeoplasm StagingRetrospective Studiesclinicopathologyelectronic medical recordsgallbladder cancertreatment

Identifiers

PMID36779618
PMCPMC10166897
OpenAlexW4320497654

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.