Evidence map›Paper›PMID 36779340›Full record

Observational studyStroke2023

Relationships of Hemoglobin Concentration, Ischemic Lesions, and Clinical Outcomes in Patients With Intracerebral Hemorrhage.

David J Roh, Amelia Boehme, Rayan Mamoon, Destiny Hooper, Azzurra Cottarelli, Robin Ji, Eric Mao, Aditya Kumar, Fernanda Carvalho Poyraz, Stacie L Demel and 9 more

Abstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Stroke, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

David J RohDepartment of Neurology, Vagelos College of Physicians and Surgeons (D.J.R., A.B., E.M., A.K., F.C.P., J.C., J. Gutierrez, M.S.V.E.), Columbia University, New York, NY.ORCID 0000-0003-1927-7686
Amelia BoehmeDepartment of Neurology, Vagelos College of Physicians and Surgeons (D.J.R., A.B., E.M., A.K., F.C.P., J.C., J. Gutierrez, M.S.V.E.), Columbia University, New York, NY.ORCID 0000-0001-7408-1075
Rayan MamoonDepartment of Epidemiology, Mailman School of Public Health (A.B., R.M., M.S.V.E.), Columbia University, New York, NY.ORCID 0000-0003-0630-8041
Destiny HooperDepartment of Neurology, University of Cincinnati, OH (D.H., S.L.D., D.W.).
Azzurra CottarelliDepartment of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons (A.C., E.A.H.), Columbia University, New York, NY.ORCID 0000-0003-4525-2028
Robin JiDepartment of Biomedical Engineering (R.J., E.K.), Columbia University, New York, NY.ORCID 0000-0003-1361-141X
Eric MaoDepartment of Neurology, Vagelos College of Physicians and Surgeons (D.J.R., A.B., E.M., A.K., F.C.P., J.C., J. Gutierrez, M.S.V.E.), Columbia University, New York, NY.ORCID 0000-0001-9967-4790
Aditya KumarDepartment of Neurology, Vagelos College of Physicians and Surgeons (D.J.R., A.B., E.M., A.K., F.C.P., J.C., J. Gutierrez, M.S.V.E.), Columbia University, New York, NY.
Fernanda Carvalho PoyrazDepartment of Neurology, Vagelos College of Physicians and Surgeons (D.J.R., A.B., E.M., A.K., F.C.P., J.C., J. Gutierrez, M.S.V.E.), Columbia University, New York, NY.ORCID 0000-0003-2488-6849
Stacie L DemelDepartment of Neurology, University of Cincinnati, OH (D.H., S.L.D., D.W.).ORCID 0000-0002-3000-8420
Vadim SpektorDepartment of Radiology, Vagelos College of Physicians and Surgeons (V.S.), Columbia University, New York, NY.ORCID 0000-0002-0967-1287
Jerina CarmonaDepartment of Neurology, Vagelos College of Physicians and Surgeons (D.J.R., A.B., E.M., A.K., F.C.P., J.C., J. Gutierrez, M.S.V.E.), Columbia University, New York, NY.ORCID 0000-0003-3317-0009
Eldad A HodDepartment of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons (A.C., E.A.H.), Columbia University, New York, NY.ORCID 0000-0002-2367-9509
Natasha IronsideDepartment of Neurological Surgery, University of Virginia, Charlottesville (N.I.).
Jose GutierrezDepartment of Neurology, Vagelos College of Physicians and Surgeons (D.J.R., A.B., E.M., A.K., F.C.P., J.C., J. Gutierrez, M.S.V.E.), Columbia University, New York, NY.ORCID 0000-0002-2175-8078
Jia GuoDepartment of Psychiatry (J. Guo), Columbia University, New York, NY.
Elisa KonofagouDepartment of Biomedical Engineering (R.J., E.K.), Columbia University, New York, NY.
Mitchell S V ElkindDepartment of Neurology, Vagelos College of Physicians and Surgeons (D.J.R., A.B., E.M., A.K., F.C.P., J.C., J. Gutierrez, M.S.V.E.), Columbia University, New York, NY.ORCID 0000-0003-2562-1156
Daniel WooDepartment of Neurology, University of Cincinnati, OH (D.H., S.L.D., D.W.).ORCID 0000-0002-2466-7155

Funding

Ethnic/Racial Variation in Intracerebral Hemorrhage (ERICH)U01NS069763 · NINDS · UNIVERSITY OF CINCINNATI · PI ANDERSON, CHRISTOPHER DAVID, DEMEL, STACIE · 2010 to 2024
$34.2M
The Impact of Oxidative Stress on Erythocyte BiologyR01HL148151 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI D'ALESSANDRO, ANGELO, KARAFIN, MATTHEW S · 2019 to 2022
$8.9M
Erythrocyte contribution to coagulopathy and cerebral oxygenation after intracerebral hemorrhageK23HL151901 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ROH, DAVID · 2021 to 2025
$950k
Racial Disparities, Influenza Like Illness and the Association between Short-term Exposure to Ambient Air Pollution and Cardiovascular OutcomesR21MD012451 · NIMHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BOEHME, AMELIA K · 2017 to 2018
$440k
Health Disparities in Sepsis as a Risk Factor for StrokeR03NS101417 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BOEHME, AMELIA K · 2017 to 2018
$160k
NHLBI NIH HHS K23 HL151901NHLBI NIH HHS R01 HL148151NIMHD NIH HHS R21 MD012451NINDS NIH HHS R03 NS101417NINDS NIH HHS U01 NS069763
6 · The paper itself

Abstract

backgroundHemoglobin concentration and diffusion-weighted imaging (DWI) ischemic lesions are separately known to be associated with poor intracerebral hemorrhage (ICH) outcomes. While hemoglobin concentrations have known relationships with ischemic stroke, it is unclear whether hemoglobin concentration is associated with DWI ischemic lesions after ICH. We sought to investigate the hypothesis that hemoglobin concentrations would associate with DWI lesions after ICH and further investigated their relationships with clinical outcomes.

methodsSupratentorial ICH patients enrolled between 2010 and 2016 to a prospective, multicenter, observational cohort study (ERICH study [Ethnic/Racial Variations of Intracerebral Hemorrhage]) were assessed. Patients from this study with baseline, admission hemoglobin, and hospitalization magnetic resonance imaging were analyzed. Hemoglobin was examined as the primary exposure variable defined as a continuous variable (g/dL). Magnetic resonance imaging DWI ischemic lesion presence was assessed as the primary radiographic outcome. Primary analyses assessed relationships of hemoglobin with DWI lesions. Secondary analyses assessed relationships of DWI lesions with poor 3-month outcomes (modified Rankin Scale score, 4-6). These analyses were performed using separate multivariable logistic regression models adjusting for relevant covariates.

resultsOf 917 patients with ICH analyzed, mean baseline hemoglobin was 13.8 g/dL (±1.9), 60% were deep ICH, and DWI lesions were identified in 27% of the cohort. In our primary analyses, increased hemoglobin, defined as a continuous variable, was associated with DWI lesions (adjusted odds ratio, 1.21 per 1 g/dL change in hemoglobin [95% CI, 1.07-1.37]) after adjusting for sex, race, ICH severity, time to magnetic resonance imaging, and acute blood pressure change. In secondary analyses, DWI lesions were associated with poor 3-month outcomes (adjusted odds ratio, 1.83 [95% CI, 1.24-2.69]) after adjusting for similar covariates.

conclusionsWe identified novel relationships between higher baseline hemoglobin concentrations and DWI ischemic lesions in patients with ICH. Further studies are required to clarify the role of hemoglobin concentration on both cerebral small vessel disease pathophysiology and ICH outcomes.

Indexed as

Cerebral HemorrhageMagnetic Resonance ImagingDiffusion Magnetic Resonance ImagingHemoglobinsHumansProspective StudiesHemoglobinscerebral hemorrhagehemoglobinshumanslogistic modelsmagnetic resonance imaging

Identifiers

PMID36779340
PMCPMC10050127

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.