Evidence map›Paper›PMID 36778914›Full record

ArticlePeptide science (Hoboken, N.J.)2023

Current Peptide Vaccine and Immunotherapy Approaches Against Alzheimer's Disease.

Chelsea Marie T Parrocha, James S Nowick

Open access · hybridAbstract read
In one paragraph

Article in Peptide science (Hoboken, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
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  8. Article
  9. Therapeutics of Alzheimer's Disease: Recent Developments.Antioxidants (Basel, Switzerland) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Chelsea Marie T ParrochaDepartment of Pharmaceutical Sciences, University of California Irvine, Irvine, CA 92697.
James S NowickDepartment of Chemistry, University of California Irvine, Irvine, CA 92697.
University of California, Irvine · US

Funding

Antibodies Against Conformationally Defined Amyloid Oligomers in Alzheimer’s DiseaseRF1AG062296 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI NOWICK, JAMES S · 2018 to 2018
$3.0M
NIA NIH HHS RF1 AG062296
6 · The paper itself

Abstract

Peptide vaccines and immunotherapies against aggregating proteins involved in the pathogenesis and progression of Alzheimer's disease (AD) - the β-amyloid peptide (Aβ) and tau - are promising therapeutic avenues against AD. Two decades of effort has led to the controversial FDA approval of the monoclonal antibody Aducanumab (Aduhelm), which has subsequentially sparked the revival and expedited review of promising monoclonal antibody immunotherapies that target Aβ. In this review, we explore the development of Aβ and tau peptide vaccines and immunotherapies with monoclonal antibodies in clinical trials against AD.

Identifiers

PMID36778914
PMCPMC9916509
OpenAlexW4283379578

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.