Evidence map›Paper›PMID 36778908›Full record

ArticleADMET & DMPK2023

Pharmaceutical and pharmacokinetic evaluation of a newly formulated multiparticulate matrix of levodopa and carbidopa.

Emelia Priscilla Imbeah, Ofosua Adi-Dako, Benoit Banga N'guessan, Kennedy Kwami Edem Kukuia, Benedicta Obenewaa Dankyi, Ismaila Adams, Ebenezer Ofori-Attah, Regina Appiah-Opong, Seth Kwabena Amponsah

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Article in ADMET & DMPK, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Emelia Priscilla ImbeahDepartment of Medical Pharmacology, University of Ghana Medical School, Accra, Ghana.
Ofosua Adi-DakoDepartment of Pharmaceutics and Microbiology, School of Pharmacy, University of Ghana, Accra, Ghana.
Benoit Banga N'guessanDepartment of Pharmacology and Toxicology, School of Pharmacy, University of Ghana, Accra, Ghana.
Kennedy Kwami Edem KukuiaDepartment of Medical Pharmacology, University of Ghana Medical School, Accra, Ghana.
Benedicta Obenewaa DankyiDepartment of Medical Pharmacology, University of Ghana Medical School, Accra, Ghana.
Ismaila AdamsDepartment of Medical Pharmacology, University of Ghana Medical School, Accra, Ghana.
Ebenezer Ofori-AttahDepartment of Clinical Pathology, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.
Regina Appiah-OpongDepartment of Clinical Pathology, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.
Seth Kwabena AmponsahDepartment of Medical Pharmacology, University of Ghana Medical School, Accra, Ghana.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Levodopa is routinely co-administered with carbidopa in the management of Parkinson's disease. Although the aforementioned combination therapy is effective, there may be fluctuating plasma levels of levodopa after oral administration. We formulated and evaluated the kinetic characteristics of the chitosan-pectin-based multiparticulate matrix of levodopa and carbidopa. Pectin was extracted from the cocoa husk, and the chitosan-pectin-based matrix was prepared by wet granulation. Formulations were evaluated for drug-excipient compatibility, drug content, precompression properties and in vitro release. For pharmacokinetic evaluation, rats were put into groups and administered either chitosan-pectin based matrix of levodopa/carbidopa, Sinemet

Indexed as

ChitosanFormulationManagementParkinson’s diseasePectinPharmacokinetics

Identifiers

PMID36778908
PMCPMC9909728

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.