ArticleFrontiers in microbiology2023
Immunomodulatory effects of complex probiotics on the immuno-suppressed mice induced by cyclophosphamide.
Article in Frontiers in microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Protective effects of Bacillus clausii in cyclophosphamide-induced immunosuppression and intestinal mucositis in rats: histopathological and inflammatory evaluation.Molecular biology reports · 2026Article
- Bifidobacterium animalis subsp. lactis and Enterococcus hirae Enhance Immunity by Modulating Gut Microbiota and Metabolic Pathways in Immunosuppressed Mice.Probiotics and antimicrobial proteins · 2026Article
- Immunomodulation of mixed postbiotics produced from Lactiplantibacillus plantarum KLDS1.0318 and KLDS1.0386 in vitro and in vivo.Archives of microbiology · 2026Article
- Evidence for bidirectional gut-spleen crosstalk in rodent models: scoping review of possible mechanisms and therapeutic implications.Journal of applied biomedicine · 2026Review
- Immune-Enhancing Effects of IBP35, a Combination ofFood science & nutrition · 2026Article
- Prebiotic-Empowered Probiotics with Gastrointestinal Stress Resistance for Enhanced Oral Therapy of Immunosuppression.Foods (Basel, Switzerland) · 2026Article
- Article
- Mechanism of Morchella polysaccharide in anti-fatigue: the role of the gut microbiota-metabolite axis in mice.NPJ science of food · 2026Article
- Effects of probiotic formulations on gastrointestinal tract morphological changes and gut microbiota in Hu lambs.Open veterinary journal · 2026Article
- Selenium-induced structural reorganization of polysaccharides from blackened jujube pomace enhances immunomodulatory activity.Frontiers in nutrition · 2026Article
- Heat-killedCurrent research in food science · 2026Article
- Purification, Structural Characterization, and Immunomodulatory Activities of a Glucan fromFoods (Basel, Switzerland) · 2025Article
- Effects of Tibetan Sheep-Derived Compound Probiotics on Growth Performance, Immune Function, Intestinal Tissue Morphology, and Intestinal Microbiota in Mice.Probiotics and antimicrobial proteins · 2025Article
- Administration of Lacticaseibacillus casei CSL3 in Swiss Mice with Immunosuppression Induced by Cyclophosphamide: Effects on Immunological, Biochemical, Oxidative Stress, and Histological Parameters.Probiotics and antimicrobial proteins · 2025Article
- [Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025Article
- Microbiome Integrity Enhances the Efficacy and Safety of Anticancer Drug.Biomedicines · 2025Review
- Immunomodulatory effects ofFrontiers in immunology · 2025Article
- Immunostimulation Signaling via Toll-like Receptor 2 Activation: A Molecular Mechanism ofNutrients · 2024Article
- Prebiotics enhance the immunomodulatory effect ofFood science & nutrition · 2024Article
- Effects ofMicroorganisms · 2024Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Previous studies have reported the beneficial effects of Methods: An immunocompromised mouse model was established by intraperitoneal injection of cyclophosphamide, which was gavage of different doses of complex probiotics and levamisole hydrochloride. The splenic and thymic indices, intestinal barrier, leukocyte and lymphocyte counts, percentage of splenic lymphocyte subpopulations, cytokine levels, and gut microbiota were determined. Results: Results showed that the complex probiotics significantly elevated the spleen and thymus indices, increased the villi and crypt depth and the goblet cells. The leukocyte and lymphocyte counts and the percentage of splenic lymphocyte subpopulations in the CTX-treated mice were significantly elevated by the complex probiotics. In addition, the cytokines (IL-6, IL-10, IL-1β, and IFN-γ) were significantly increased after complex probiotic treatment. The complex probiotics restored the gut microbiota structure to the pattern of the control group by reducing the ratio of Firmicutes/Bacteroidetes and enhancing the relative abundances of specific microbiota that produced short-chain fatty acids. Discussion: This study provides theoretical support for the immunity-enhancing function of the complex probiotics as well as a pharmacological basis for its further development and utilization.
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