ReviewFrontiers in microbiology2023
Infection and innate immune mechanism of goose astrovirus.
Review in Frontiers in microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Goose kidney organoids: A new model for studying the metabolic mechanism of goose astrovirus-induced gout.Poultry science · 2026Article
- Duplex MIRA assays for simultaneous detection of novel goose astrovirus and goose circovirus.BMC veterinary research · 2026Article
- Splenic transcriptomic profiling reveals innate immune responses and RIG-I-like receptor signaling in goslings infected with goose astrovirus.Frontiers in veterinary science · 2026Article
- Goose Astrovirus Type 2 Causes Intestinal Injury and Disrupts Homeostasis in Goslings.Veterinary sciences · 2025Article
- AGXT-Driven Bile Acid Dysregulation Triggers Viral Gout in Astrovirus-Infected Jiangnan White Geese.Veterinary sciences · 2025Article
- Review
- Effects and potential pathways of goose astrovirus infection on gosling hepatic lipid metabolism.Frontiers in microbiology · 2025Article
- Article
- On-Site Rapid and Specific Detection of Novel Emerging Goose Astrovirus Using a Nanobody-Based Colloidal Gold Immunochromatographic Strip.Transboundary and emerging diseases · 2025Article
- Alteration of gut microbiome in goslings infected with goose astrovirus.Poultry science · 2024Article
- Resolving candidate genes of duck ovarian tissue transplantation via RNA-Seq and expression network analyses.Poultry science · 2024Article
- Molecular characterization of a virulent goose astrovirus genotype-2 with high mortality in vitro and in vivo.Poultry science · 2024Article
Corrections and comments
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Authors and funding
20 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Goose astrovirus (GAstV, genus Avian Astrovirus, family Astrovirus) was first discovered in 2005, but was not considered as a pathogen of gosling gout until 2016. Since then, goose astrovirus has erupted in Chinese goslings, causing at most 50% of gosling deaths. By December 2022, the disease had become epidemic and prevailed in goose farms in Jiangsu, Shandong, Anhui, Henan, Guangdong, Liaoning, Sichuan and other places in China. The disease mainly affects goslings within 3 weeks old. The typical symptoms of goose astrovirus are large deposits of urate in the viscera, joint cavity and ureter surface of infected goslings. Goose astrovirus infection can trigger high levels of iNOS, limiting goose astrovirus replication. The ORF2 domain P2 of the goose astrovirus activates the OASL protein, limiting its replication. Goose astrovirus can also activate pattern recognition receptors (RIG-I, MDA-5, TLR-3), causing an increase in MHC-Ia, MHC-Ib and CD81 mRNA, activating humoral and cellular immunity, thereby hindering virus invasion. Goose astrovirus also regulates the activation of IFNs and other antiviral proteins (Mx1, IFITM3, and PKR) in the spleens and kidneys to inhibit viral replication. The innate immune response process in goslings also activates TGF-β, which may be closely related to the immune escape of goose astrovirus. Gaining insight into the infection and innate immune mechanism of goose astrovirus can help researchers study and prevent the severe disease in goslings better.
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