ReviewFrontiers in plant science2023
Genetic approaches in improving biotechnological production of taxanes: An update.
Review in Frontiers in plant science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Investigating synergistic effects of key medium components and pectin elicitor on taxane fermentation in Neopestalotiopsis vitis: A Box-Behnken response surface methodology approach.International microbiology : the official journal of the Spanish Society for Microbiology · 2026Article
- Recent advances inFrontiers in plant science · 2026Review
- The biosynthesis and diversity of taxanes: From pathway elucidation to engineering and synthetic biology.Plant communications · 2025Review
- Navigating the challenges of engineering composite specialized metabolite pathways in plants.The Plant journal : for cell and molecular biology · 2025Review
- Phyllosphere mycobiome in two Lycopodiaceae plant species: unraveling potential HupA-producing fungi and fungal interactions.Frontiers in plant science · 2025Article
- Recent advances in paclitaxel biosynthesis and regulation.Journal of experimental botany · 2025Review
- Plasma-activated water modulates taxanes production and phenylalanineammonia-lyase activity in Taxus baccata cell culture.PloS one · 2025Article
- Article
- Paclitaxel - a Product of Fungal Secondary Metabolism or an Artefact?Planta medica · 2024Review
- Endophytic fungi as a potential source of anti-cancer drug.Archives of microbiology · 2024Review
- Overexpression of BAPT and DBTNBT genes in Taxus baccata in vitro cultures to enhance the biotechnological production of paclitaxel.Plant biotechnology journal · 2024Article
- Transcriptomics and Physiological Analyses Reveal Changes in Paclitaxel Production and Physiological Properties inPlants (Basel, Switzerland) · 2023Article
- Insights into Taxol® biosynthesis by endophytic fungi.Applied microbiology and biotechnology · 2023Review
- Exploring the Interplay between Metabolic Pathways and Taxane Production in ElicitedPlants (Basel, Switzerland) · 2023Article
- Impact of Elicitation on Plant Antioxidants Production inAntioxidants (Basel, Switzerland) · 2023Article
- Targeted control of supporting pathways in paclitaxel biosynthesis with CRISPR-guided methylation.Frontiers in bioengineering and biotechnology · 2023Article
- Enabling the study of gene function in gymnosperms: Virus-induced gene silencing inApplications in plant sciencesArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Paclitaxel (PTX) and its derivatives are diterpene alkaloids widely used as chemotherapeutic agents in the treatment of various types of cancer. Due to the scarcity of PTX in nature, its production in cell cultures and plant organs is a major challenge for plant biotechnology. Although significant advances have been made in this field through the development of metabolic engineering and synthetic biology techniques, production levels remain insufficient to meet the current market demand for these powerful anticancer drugs. A key stumbling block is the difficulty of genetically transforming the gymnosperm
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Registered trials
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