Evidence map›Paper›PMID 36778507›Full record

ArticleResearch square2023

A Higher Dysregulation Burden of Brain DNA Methylation in Female Patients Implicated in the Sex Bias of Schizophrenia.

Chao Chen, Jiaqi Zhou, Yan Xia, Miao Li, Yu Chen, Jiacheng Dai, Chunyu Liu

Open access · greenAbstract readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Chao ChenCentral South University.ORCID 0000-0002-5114-2282
Jiaqi ZhouCentral South University.
Yan XiaCentral South University.
Miao LiCentral South University.
Yu ChenCentral South University.
Jiacheng DaiCentral South University.
Chunyu LiuSUNY Upstate Medical University.ORCID 0000-0002-5986-4415
Central South University · CNSUNY Upstate Medical University · US

Funding

2/2-Discovery and validation of neuronal enhancers associated with the development of psychiatric disordersU01MH116489 · NIMH · UNIVERSITY OF CHICAGO · PI GAYNOR, SOPHIA, GESCHWIND, DANIEL H · 2018 to 2022
$4.5M
1/2 Measuring translational dynamics and the proteome to identify potential brain biomarkers for psychiatric diseaseR01MH110920 · NIMH · UPSTATE MEDICAL UNIVERSITY · PI LIU, CHUNYU · 2016 to 2019
$2.0M
1/3 High-resolution mapping of cell type-specific DNA (hydroxy)methylation in the human brain during postnatal development and in psychiatric disease.U01MH122591 · NIMH · UPSTATE MEDICAL UNIVERSITY · PI LIU, CHUNYU · 2020 to 2022
$483k
NIMH NIH HHS R01 MH110920NIMH NIH HHS U01 MH116489NIMH NIH HHS U01 MH122591
6 · The paper itself

Abstract

Sex differences are pervasive in schizophrenia (SCZ), but the extent and magnitude of DNA methylation (DNAm) changes underlying these differences remain uncharacterized. In this study, sex-stratified differential DNAm analysis was performed in postmortem brain samples from 117 SCZ and 137 controls, partitioned into discovery and replication datasets. Three differentially methylated positions (DMPs) were identified (adj.

Identifiers

PMID36778507
PMCPMC9915764
OpenAlexW4318575294

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.