Evidence map›Paper›PMID 36778463›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Chromosome 10q24.32 Variants Associate with Brain Arterial Diameters in Diverse Populations: A Genome-Wide Association Study.

Minghua Liu, Farid Khasiyev, Sanjeev Sariya, Antonio Spagnolo-Allende, Danurys L Sanchez, Howard Andrews, Qiong Yang, Alexa Beiser, Ye Qiao, Emy A Thomas and 13 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors at 8 institutions in 2 countries.

Minghua LiuDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Farid KhasiyevDepartment of Neurology, Saint Louis University School of Medicine, St. Louis, MO, USA.
Sanjeev SariyaDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Antonio Spagnolo-AllendeDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Danurys L SanchezDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Howard AndrewsBiostatistics Department, Mailman School of Public Health, Columbia University, New York, NY, USA.
Qiong YangDepartment of Biostatistics, School of Public Health, Boston University, Boston, MA, USA.
Alexa BeiserDepartment of Biostatistics, School of Public Health, Boston University, Boston, MA, USA.
Ye QiaoJohns Hopkins University School of Medicine, Baltimore, MD, USA.
Emy A ThomasBrown Foundation Institute of Molecular Medicine, Mc Govern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Jose Rafael RomeroDepartment of Neurology, Boston University School of Medicine, Boston, MA, USA.
Tatjana RundekDepartment of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.
Adam M BrickmanDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Jennifer J ManlyDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Mitchell Sv ElkindDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Sudha SeshadriDepartment of Neurology, Boston University School of Medicine, Boston, MA, USA.
Christopher ChenMemory Aging and Cognition Center, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Ralph L SaccoDepartment of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.
Saima HilalMemory Aging and Cognition Center, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Bruce A WassermanJohns Hopkins University School of Medicine, Baltimore, MD, USA.
Giuseppe TostoDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Myriam FornageBrown Foundation Institute of Molecular Medicine, Mc Govern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Jose GutierrezDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Columbia University · USBoston University · USBrown Foundation · USNational University of Singapore · SGUniversity of Miami · USJohns Hopkins University · USSaint Louis University · USUniversity of Maryland, Baltimore · US

Funding

Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
ARIC Neurocognitive Study (ARIC-NCS) Renewal 2023-2028U01HL096812 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JOSEF CORESH, THOMAS H MOSLEY · 2010 to 2026
$65.7M
FRAMINGHAM HEART STUDY - YEAR 5 EXAM75N92019D00031 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · 2019 to 2024
$29.8M
Genome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2M
STROKE INCIDENCE AND RISK FACTORS IN A TRI-ETHNIC REGIONR01NS029993 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ELKIND, MITCHELL S, SACCO, RALPH L. · 1993 to 2019
$19.2M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - COORDINATING CENTER - TASK AREA B.2 AND B.375N92022D00001 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID · 2022 to 2025
$13.7M
Epidemiological and Genetic Investigations of Blood-Based Biomarkers for Alzheimer's Disease in the Multiethnic, Washington Heights, Inwood, Columbia Aging Project (WHICAP)R01AG072474 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BRICKMAN, ADAM M, MANLY, JENNIFER JAIE · 2021 to 2025
$13.3M
ARIC Neurocognitive Study (ARIC-NCS) Renewal 2 of 5U01HL096917 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI MOSLEY, THOMAS H · 2010 to 2018
$11.9M
Epidemiology of Biomarkers of Risk and Progression in LOADR01AG037212 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P, SCHUPF, NICOLE · 2010 to 2015
$10.1M
Genetic Epidemiology of Cerebrovascular Factors in Alzheimer's DiseaseRF1AG054023 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P · 2016 to 2018
$8.9M
Proteomic Profiling of Precise Exercise Pathophenotypes Across the HFpEF SpectrumR01HL131029 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Gregory Dyer Lewis, Matthew G. Nayor · 2016 to 2026
$7.7M
ARIC Neurocognitive Study (ARIC-NCS) Renewal UNC 4 of 5U01HL096899 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID J · 2010 to 2018
$7.5M
NCRR NIH HHS UL1 RR025005NHGRI NIH HHS U01 HG004402NHLBI NIH HHS 75N92019D00031NHLBI NIH HHS 75N92022D00001NHLBI NIH HHS 75N92022D00002NHLBI NIH HHS 75N92022D00003NHLBI NIH HHS 75N92022D00004NHLBI NIH HHS 75N92022D00005NHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS N01 HC025195NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01 HL131029NHLBI NIH HHS U01 HL096812NHLBI NIH HHS U01 HL096814NHLBI NIH HHS U01 HL096899NHLBI NIH HHS U01 HL096902NHLBI NIH HHS U01 HL096917NIA NIH HHS R01 AG037212NIA NIH HHS R01 AG047645NIA NIH HHS R01 AG054491NIA NIH HHS R01 AG057709NIA NIH HHS R01 AG066162NIA NIH HHS R01 AG072474NIA NIH HHS RF1 AG054023NIA NIH HHS U01 AG052409NINDS NIH HHS R01 NS029993NINDS NIH HHS R01 NS036286
6 · The paper itself

Abstract

Background: Brain arterial diameters are novel imaging biomarkers of cerebrovascular disease, cognitive decline and dementia. Traditional vascular risk factors have been associated with brain arterial diameters but whether there may be genetic determinants of brain arterial diameters is unknown. Results: We studied 4150 participants from six geographically diverse population-based cohorts (40% European, 14% African, 22% Hispanic, 24% Asian ancestries). We measured brain arterial diameters for 13 segments and averaged them to obtain a global measure of brain arterial diameters as well as the posterior and anterior circulations. A genome-wide association study (GWAS) revealed 14 variants at one locus associated with global brain arterial diameter at genome-wide significance (P<5×10 Conclusion: Our study reveals three novel risk loci (CNNM2, NT5C2 and AS3MT) associated with brain arterial diameters. Our finding may elucidate the mechanisms by which brain arterial diameters influence the risk of stroke and dementia.

Indexed as

Chromosome 10q24.32Cyclin and CBS Domain Divalent Metal Cation Transport Mediator 2 (CNNM2)Genome-wide association studiesLarger brain arterial diameters

Identifiers

PMID36778463
PMCPMC9915818
OpenAlexW4319037361

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.