Evidence map›Paper›PMID 36778460›Full record

ArticlebioRxiv : the preprint server for biology2023

Tregs constrain CD8

Joseph R Palmeri, Brianna M Lax, Joshua M Peters, Lauren Duhamel, Jordan A Stinson, Luciano Santollani, Emi A Lutz, William Pinney, Bryan D Bryson, K Dane Wittrup

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

  • Updated by
    CD82024
5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Joseph R PalmeriKoch Institute for Integrative Cancer Research; Cambridge, MA.
Brianna M LaxKoch Institute for Integrative Cancer Research; Cambridge, MA.
Joshua M PetersDepartment of Biological Engineering of Massachusetts Institute of Technology (MIT); Cambridge, MA.
Lauren DuhamelKoch Institute for Integrative Cancer Research; Cambridge, MA.
Jordan A StinsonKoch Institute for Integrative Cancer Research; Cambridge, MA.
Luciano SantollaniKoch Institute for Integrative Cancer Research; Cambridge, MA.
Emi A LutzKoch Institute for Integrative Cancer Research; Cambridge, MA.
William PinneyKoch Institute for Integrative Cancer Research; Cambridge, MA.
Bryan D BrysonDepartment of Biological Engineering of Massachusetts Institute of Technology (MIT); Cambridge, MA.
K Dane WittrupKoch Institute for Integrative Cancer Research; Cambridge, MA.
IIT@MIT · USIntegrative Medicine Institute · USRagon Institute of MGH, MIT and Harvard · US

Funding

VIRUS PRODUCTION COREP30CA014051 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI MATTHEW G. VANDER HEIDEN · 1985 to 2026
$93.9M
Localized immunotherapy using alum-binding therapeuticsR01EB031082 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI IRVINE, DARRELL J, WITTRUP, KARL DANE · 2021 to 2024
$2.1M
Intratumoral Cytokine Immunotherapy Studies in Companion Canine Cancer ModelsR01CA271243 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI FAN, TIMOTHY M, WITTRUP, KARL DANE · 2022 to 2025
$2.0M
NCI NIH HHS P30 CA014051NCI NIH HHS R01 CA271243NIBIB NIH HHS R01 EB031082
6 · The paper itself

Abstract

Although co-stimulation of T cells with agonist antibodies targeting 4-1BB (CD137) improves antitumor immune responses in preclinical studies, clinical development has been hampered by on-target, off-tumor toxicity. Here, we report the development of a tumor-anchored ɑ4-1BB agonist (ɑ4-1BB-LAIR), which consists of an ɑ4-1BB antibody fused to the collagen binding protein LAIR. While combination treatment with an antitumor antibody (TA99) displayed only modest efficacy, simultaneous depletion of CD4

Identifiers

PMID36778460
PMCPMC9915483
OpenAlexW4319812051

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.