Evidence map›Paper›PMID 36778456›Full record

ArticlebioRxiv : the preprint server for biology2023

Adolescent neurostimulation of dopamine circuit reverses genetic deficits in frontal cortex function.

Surjeet Mastwal, Xinjian Li, Rianne Stowell, Matthew Manion, Wenyu Zhang, Nam-Shik Kim, Ki-Jun Yoon, Hongjun Song, Guo-Li Ming, Kuan Hong Wang

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Surjeet MastwalUnit on Neural Circuits and Adaptive Behaviors, National Institute of Mental Health, Bethesda, MD 20892.
Xinjian LiUnit on Neural Circuits and Adaptive Behaviors, National Institute of Mental Health, Bethesda, MD 20892.
Rianne StowellDepartment of Neuroscience, Del Monte Institute for Neuroscience, University of Rochester Medical Center, Rochester, NY 14642.
Matthew ManionUnit on Neural Circuits and Adaptive Behaviors, National Institute of Mental Health, Bethesda, MD 20892.
Wenyu ZhangUnit on Neural Circuits and Adaptive Behaviors, National Institute of Mental Health, Bethesda, MD 20892.
Nam-Shik KimDepartment of Neuroscience, Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Ki-Jun YoonDepartment of Neuroscience, Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Hongjun SongDepartment of Neuroscience, Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Guo-Li MingDepartment of Neuroscience, Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Kuan Hong WangUnit on Neural Circuits and Adaptive Behaviors, National Institute of Mental Health, Bethesda, MD 20892.
University of Pennsylvania · USNational Institute of Mental Health · USUniversity of Rochester Medical Center · US

Funding

Role of CACNA1C - a shared risk gene in neuropsychiatric disordersU19MH106434 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI O'SHEA, K SUE SUE · 2016 to 2020
$13.8M
Molecular and Cellular Mechanisms of Experience-Dependent Cortical ProcessingZIAMH002897 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI WANG, KUAN · 2009 to 2018
$12.9M
Continuous Neurogenesis in the Mammalian HippocampusR35NS116843 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI HONGJUN SONG · 2020 to 2026
$6.9M
Functional roles of genetic risk factors for brain disorders in neurogenesis and neurodevelopmentR35NS097370 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI MING, GUO-LI · 2017 to 2024
$6.7M
Fronto-insular network in cognitive-affective interactions during decision-makingR01MH127737 · NIMH · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI Kuan Hong Wang, Yi Zuo · 2022 to 2026
$2.8M
Adolescent plasticity of the dopaminergic mesofrontal circuit: cellular mechanisms and behavioral rolesF32MH124298 · NIMH · UNIVERSITY OF ROCHESTER · PI STOWELL, RIANNE · 2021 to 2022
$143k
Intramural NIH HHS ZIA MH002897NIMH NIH HHS F32 MH124298NIMH NIH HHS R01 MH127737NIMH NIH HHS U19 MH106434NINDS NIH HHS R35 NS097370NINDS NIH HHS R35 NS116843
6 · The paper itself

Abstract

Dopamine system dysfunction is commonly implicated in adolescent-onset neuropsychiatric disorders. Although psychosis symptoms can be alleviated by antipsychotics, cognitive symptoms remain unresponsive to such pharmacological treatments and novel research paradigms investigating the circuit substrates underlying cognitive deficits are critically needed. The frontal cortex and its dopaminergic input from the midbrain are implicated in cognitive functions and undergo maturational changes during adolescence. Here, we used mice carrying mutations in the

Identifiers

PMID36778456
PMCPMC9915739
OpenAlexW4319265493

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.