Evidence map›Paper›PMID 36778455›Full record

ArticlebioRxiv : the preprint server for biology2023

The Clustered Gamma Protocadherin Pcdhγc4 Isoform Regulates Cortical Interneuron Programmed Cell Death in the Mouse Cortex.

Walter R Mancia Leon, David M Steffen, Fiona Dale-Huang, Benjamin Rakela, Arnar Breevoort, Ricardo Romero-Rodriguez, Andrea R Hasenstaub, Michael P Stryker, Joshua A Weiner, Arturo Alvarez-Buylla

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PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Walter R Mancia LeonDepartment of Neurological Surgery and The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, United States.
David M SteffenDepartment of Neurological Surgery and The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, United States.
Fiona Dale-HuangDepartment of Neurological Surgery and The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, United States.
Benjamin RakelaDepartment of Physiology and Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, United States.
Arnar BreevoortDepartment of Physiology and Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, United States.
Ricardo Romero-RodriguezDepartment of Neurological Surgery and The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, United States.
Andrea R HasenstaubDepartment of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, United States.
Michael P StrykerDepartment of Physiology and Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, United States.
Joshua A WeinerIowa Neuroscience Institute, The University of Iowa, Iowa City, IA 52242.
Arturo Alvarez-BuyllaDepartment of Neurological Surgery and The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, United States.
University of California, San Francisco · USUniversity of Iowa · US

Funding

Rapid-Prototyping and Design CoreP30EY002162 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LAMBA, DEEPAK ASHOK · 1985 to 2024
$16.8M
NEUROGENESIS IN THE ADULT VERTEBRATE BRAINR01NS028478 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ALVAREZ-BUYLLA, ARTURO · 1996 to 2024
$8.6M
DEVELOPMENT &PLASTICITY OF THE VISUAL SYSTEMR01EY002874 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STRYKER, MICHAEL P · 1986 to 2022
$6.4M
Elucidating Functions of the Gamma-Protocadherins in CNS Synapse DevelopmentR01NS055272 · NINDS · UNIVERSITY OF IOWA · PI WEINER, JOSHUA A · 2007 to 2020
$5.1M
Elucidating Novel Features of Visual Processing and Physiological Connectivity from Retina to Primary Visual CortexR01EY031059 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Gregory Darin Field, Alexander C Huk · 2020 to 2026
$4.7M
Clustered protocadherin regulation of cortical interneuron survival circuit assembly and plasticityR01MH122478 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ALVAREZ-BUYLLA, ARTURO, HASENSTAUB, ANDREA RAYNE · 2020 to 2024
$3.7M
Cortical circuitry supporting flexible audiovisual interactions and behaviorsR01NS116598 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HASENSTAUB, ANDREA RAYNE · 2023 to 2024
$1.0M
Reducing Diversity at the Gamma Protocadherin Locus by CRISPR TargetingR21NS090030 · NINDS · JACKSON LABORATORY · PI BURGESS, ROBERT W., WEINER, JOSHUA A · 2014 to 2015
$506k
NEI NIH HHS P30 EY002162NEI NIH HHS R01 EY002874NEI NIH HHS R01 EY031059NIMH NIH HHS R01 MH122478NINDS NIH HHS R01 NS028478NINDS NIH HHS R01 NS055272NINDS NIH HHS R01 NS116598NINDS NIH HHS R21 NS090030
6 · The paper itself

Abstract

Cortical function critically depends on inhibitory/excitatory balance. Cortical inhibitory interneurons (cINs) are born in the ventral forebrain and migrate into cortex, where their numbers are adjusted by programmed cell death. Previously, we showed that loss of clustered gamma protocadherins (

Identifiers

PMID36778455
PMCPMC9915683
OpenAlexW4319223070

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.