Evidence map›Paper›PMID 36778428›Full record

ArticlebioRxiv : the preprint server for biology2023

Path integration selectively predicts midlife risk of Alzheimer's disease.

Coco Newton, Marianna Pope, Catarina Rua, Richard Henson, Zilong Ji, Neil Burgess, Christopher T Rodgers, Matthias Stangl, Maria-Eleni Dounavi, Andrea Castegnaro and 9 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 13 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 8 institutions in 5 countries.

Coco NewtonDepartment of Psychiatry, University of Cambridge; Cambridge, UK.
Marianna PopeDepartment of Psychiatry, University of Cambridge; Cambridge, UK.
Catarina RuaWolfson Brain Imaging Centre, University of Cambridge; Cambridge, UK.
Richard HensonDepartment of Psychiatry, University of Cambridge; Cambridge, UK.
Zilong JiInstitute of Cognitive Neuroscience, UCL; London, UK.
Neil BurgessInstitute of Cognitive Neuroscience, UCL; London, UK.
Christopher T RodgersWolfson Brain Imaging Centre, University of Cambridge; Cambridge, UK.
Matthias StanglJane and Terry Semel Institute for Neuroscience and Human Behavior, University of California; Los Angeles, USA.
Maria-Eleni DounaviDepartment of Psychiatry, University of Cambridge; Cambridge, UK.
Andrea CastegnaroInstitute of Cognitive Neuroscience, UCL; London, UK.
Ivan KoychevDepartment of Psychiatry, Oxford University; Oxford, UK.
Paresh MalhotraDepartment of Brain Sciences, Imperial College London; London, UK.
Thomas WolbersGerman Centre for Neurodegenerative Diseases (DZNE); Magdeburg, Germany.
Karen RitchieInserm, Institut de Neurosciences; Montpellier, France.
Craig W RitchieCentre for Dementia Prevention, University of Edinburgh; Edinburgh, UK.
John O'BrienDepartment of Psychiatry, University of Cambridge; Cambridge, UK.
Li SuDepartment of Psychiatry, University of Cambridge; Cambridge, UK.
Dennis ChanInstitute of Cognitive Neuroscience, UCL; London, UK.
PREVENT Dementia Research Programme
University of Cambridge · GBInstitut des Sciences Cognitives Marc Jeannerod · FRAlzheimer Scotland · GBGerman Center for Neurodegenerative Diseases · DEImperial College London · GBInserm · FRUniversity of Oxford · GBUniversity of Southern California · US

Funding

Neural mechanisms of spatial representations beyond the selfK99NS126715 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI STANGL, MATTHIAS · 2022 to 2023
$232k
NINDS NIH HHS K99 NS126715Wellcome Trust
6 · The paper itself

Abstract

The entorhinal cortex (EC) is the first cortical region to exhibit neurodegeneration in Alzheimer's disease (AD), associated with EC grid cell dysfunction. Given the role of grid cells in path integration, we predicted that path integration impairment would represent the first behavioural change in adults at-risk of AD. Using immersive virtual reality, we found that midlife path integration impairments predicted both hereditary and physiological AD risk, with no corresponding impairment on tests of episodic memory or other spatial behaviours. Impairments related to poorer angular estimation and were associated with hexadirectional grid-like fMRI signal in the posterior-medial EC. These results indicate that altered path integration may represent the transition point from at-risk state to disease onset in AD, prior to impairment in other cognitive domains.

Identifiers

PMID36778428
PMCPMC9915680
OpenAlexW4319232639

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.