Evidence map›Paper›PMID 36778402›Full record

ArticlebioRxiv : the preprint server for biology2023

Perturb-tracing enables high-content screening of multiscale 3D genome regulators.

Yubao Cheng, Mengwei Hu, Bing Yang, Tyler B Jensen, Tianqi Yang, Ruihuan Yu, Zhaoxia Ma, Jonathan S D Radda, Shengyan Jin, Chongzhi Zang and 1 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 12 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Yubao ChengDepartment of Genetics, Yale School of Medicine, Yale University, New Haven, CT 06510, USA.
Mengwei HuDepartment of Genetics, Yale School of Medicine, Yale University, New Haven, CT 06510, USA.ORCID 0000-0003-0966-8720
Bing YangDepartment of Genetics, Yale School of Medicine, Yale University, New Haven, CT 06510, USA.
Tyler B JensenDepartment of Genetics, Yale School of Medicine, Yale University, New Haven, CT 06510, USA.
Tianqi YangDepartment of Genetics, Yale School of Medicine, Yale University, New Haven, CT 06510, USA.
Ruihuan YuDepartment of Genetics, Yale School of Medicine, Yale University, New Haven, CT 06510, USA.
Zhaoxia MaCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, 22908, USA.
Jonathan S D RaddaDepartment of Genetics, Yale School of Medicine, Yale University, New Haven, CT 06510, USA.
Shengyan JinDepartment of Genetics, Yale School of Medicine, Yale University, New Haven, CT 06510, USA.
Chongzhi ZangCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, 22908, USA.ORCID 0000-0003-4812-3627
Siyuan WangDepartment of Genetics, Yale School of Medicine, Yale University, New Haven, CT 06510, USA.ORCID 0000-0001-6550-4064
Yale University · USUniversity of Virginia · USYale Cancer Center · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007205 · NIGMS · YALE UNIVERSITY · PI KAZMIERCZAK, BARBARA I · 1985 to 2019
$42.9M
PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007499 · NIGMS · YALE UNIVERSITY · PI CARLSON, JOHN R, REINKE, VALERIE J · 1985 to 2022
$13.9M
Integrative computational models for functional epigenomics and transcriptional regulationR35GM133712 · NIGMS · UNIVERSITY OF VIRGINIA · PI Chongzhi Zang · 2019 to 2026
$3.4M
Building the 3D genomic regulatomeDP2GM137414 · NIGMS · YALE UNIVERSITY · PI WANG, SIYUAN · 2019 to 2019
$2.5M
Integrative single-cell spatial genomic, transcriptomic, and epigenetic imaging in mammalian tissueR01HG011245 · NHGRI · YALE UNIVERSITY · PI WANG, SIYUAN · 2020 to 2023
$2.1M
Developing next-generation high-content image-based genetic screens for multi-omic spatial phenotypesR01HG013503 · NHGRI · YALE UNIVERSITY · PI Siyuan Wang · 2024 to 2026
$2.0M
Multiplexed imaging of chromatin folding and RNA profiles in cancerR33CA251037 · NCI · YALE UNIVERSITY · PI MUZUMDAR, MANDAR DEEPAK, WANG, SIYUAN · 2020 to 2020
$1.2M
Spatial omics technologies to map the senescent cell microenvironmentUG3CA268202 · NCI · BROWN UNIVERSITY · PI MA, JIAN, NERETTI, NICOLA · 2021 to 2022
$916k
NCI NIH HHS R33 CA251037NCI NIH HHS UG3 CA268202NHGRI NIH HHS R01 HG011245NHGRI NIH HHS R01 HG013503NIGMS NIH HHS DP2 GM137414NIGMS NIH HHS R35 GM133712NIGMS NIH HHS T32 GM007205NIGMS NIH HHS T32 GM007499
6 · The paper itself

Abstract

Three-dimensional (3D) genome organization becomes altered during development, aging, and disease

Identifiers

PMID36778402
PMCPMC9915657
OpenAlexW4319040121

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.