Evidence map›Paper›PMID 36778398›Full record

ArticlebioRxiv : the preprint server for biology2023

Elamipretide Improves ADP Sensitivity in Aged Mitochondria by Increasing Uptake through the Adenine Nucleotide Translocator (ANT).

Gavin Pharaoh, Varun Kamat, Sricharan Kannan, Rudolph S Stuppard, Jeremy Whitson, Miguel Martin-Perez, Wei-Jun Qian, Michael J MacCoss, Judit Villen, Peter Rabinovitch and 3 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Gavin PharaohDepartment of Radiology, University of Washington, Seattle, Washington, 98195, USA.
Varun KamatDepartment of Medicine, University of Washington, Seattle, Washington, 98195, USA.
Sricharan KannanDepartment of Radiology, University of Washington, Seattle, Washington, 98195, USA.
Rudolph S StuppardDepartment of Radiology, University of Washington, Seattle, Washington, 98195, USA.
Jeremy WhitsonDepartment of Biology, High Point University, High Point, NC, 27268, USA.
Miguel Martin-PerezDepartment of Cell Biology, Physiology and Immunology, University of Barcelona, Barcelona, 08028, Spain.
Wei-Jun QianIntegrative Omics Group, Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, 99352, USA.
Michael J MacCossDepartment of Genome Sciences, University of Washington, Seattle, WA, 98195, USA.
Judit VillenDepartment of Genome Sciences, University of Washington, Seattle, WA, 98195, USA.
Peter RabinovitchDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, 98195, USA.
Matthew D CampbellDepartment of Radiology, University of Washington, Seattle, Washington, 98195, USA.
Ian R SweetDepartment of Medicine, University of Washington, Seattle, Washington, 98195, USA.
David J MarcinekDepartment of Radiology, University of Washington, Seattle, Washington, 98195, USA.
University of Washington · USCalifornia Institute for Regenerative Medicine · USHigh Point University · USPacific Northwest National Laboratory · USUniversitat de Barcelona · ES

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Sakeneh Zraika · 1986 to 2026
$41.4M
SPECIFICITY OF OXYGEN DNA DAMAGE AND MUTAGENESISP01AG001751 · NIA · UNIVERSITY OF WASHINGTON · PI PRUSKY, GLEN THOMAS · 1985 to 2021
$29.6M
UW Center for Translational Muscle Research (Overall Application)P30AR074990 · NIAMS · UNIVERSITY OF WASHINGTON · PI Jennifer Michelle Davis, DANIEL RAFTERY · 2019 to 2026
$7.5M
Biological Mechanisms of Healthy Aging Training GrantT32AG066574 · NIA · UNIVERSITY OF WASHINGTON · PI David J. Marcinek, Jessica E Young · 2020 to 2026
$5.3M
Structure-function changes in the mitochondrial interactome with ageR56AG070096 · NIA · UNIVERSITY OF WASHINGTON · PI BRUCE, JAMES EDWARD, MARCINEK, DAVID J. · 2021 to 2021
$362k
NIAMS NIH HHS P30 AR074990NIA NIH HHS P01 AG001751NIA NIH HHS R56 AG070096NIA NIH HHS T32 AG066574NIDDK NIH HHS P30 DK017047
6 · The paper itself

Abstract

Aging muscle experiences functional decline in part mediated by impaired mitochondrial ADP sensitivity. Elamipretide (ELAM) rapidly improves physiological and mitochondrial function in aging and binds directly to the mitochondrial ADP transporter ANT. We hypothesized that ELAM improves ADP sensitivity in aging leading to rescued physiological function. We measured the response to ADP stimulation in young and old muscle mitochondria with ELAM treatment, Abstract Figure:

Identifiers

PMID36778398
PMCPMC9915686
OpenAlexW4319232444

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.