Evidence map›Paper›PMID 36778390›Full record

ArticlebioRxiv : the preprint server for biology2023

Histone bivalency regulates the timing of cerebellar granule cell development.

Kärt Mätlik, Eve-Ellen Govek, Matthew R Paul, C David Allis, Mary E Hatten

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kärt MätlikLaboratory of Developmental Neurobiology, Rockefeller University, 10065, New York, NY, USA.
Eve-Ellen GovekLaboratory of Developmental Neurobiology, Rockefeller University, 10065, New York, NY, USA.
Matthew R PaulBioinformatics Resource Center, Rockefeller University, 10065, New York, NY, USA.
C David AllisLaboratory of Chromatin Biology and Epigenetics, Rockefeller University, 10065, New York, NY, USA.
Mary E HattenLaboratory of Developmental Neurobiology, Rockefeller University, 10065, New York, NY, USA.
Rockefeller University · US

Funding

Chromatin Changes During CNS Migration and Circuit FormationR21NS114545 · NINDS · ROCKEFELLER UNIVERSITY · PI HATTEN, MARY ELIZABETH · 2019 to 2020
$466k
NINDS NIH HHS R21 NS114545
6 · The paper itself

Abstract

Developing neurons undergo a progression of morphological and gene expression changes as they transition from neuronal progenitors to mature, multipolar neurons. Here we use RNA-seq and H3K4me3 and H3K27me3 ChIP-seq to analyze how chromatin modifications control gene expression in a specific type of CNS neuron, the mouse cerebellar granule cell (GC). We find that in proliferating GC progenitors (GCPs), H3K4me3/H3K27me3 bivalency is common at neuronal genes and undergoes dynamic changes that correlate with gene expression during migration and circuit formation. Expressing a fluorescent sensor for bivalent H3K4me3 and H3K27me3 domains revealed subnuclear bivalent foci in proliferating GCPs. Inhibiting H3K27 methyltransferases EZH1 and EZH2

Identifiers

PMID36778390
PMCPMC9915618
OpenAlexW4319230482

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.