Evidence map›Paper›PMID 36778381›Full record

ArticlebioRxiv : the preprint server for biology2023

Antimicrobial overproduction sustains intestinal inflammation by inhibiting

Kyung Ku Jang, Thomas Heaney, Mariya London, Yi Ding, Frank Yeung, Defne Ercelen, Ying-Han Chen, Jordan Axelrad, Sakteesh Gurunathan, A Marijke Keestra-Gounder and 3 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Kyung Ku JangORCID 0000-0002-0403-1256
Thomas Heaney
Mariya London
Yi Ding
Frank Yeung
Defne Ercelen
Ying-Han Chen
Jordan Axelrad
Sakteesh Gurunathan
A Marijke Keestra-Gounder
Matthew E GriffinORCID 0000-0001-9549-4418
Howard C Hang
Ken Cadwell
New York University · USScripps Research Institute · USGeisinger Health System · USTranslational Therapeutics (United States) · USUniversity of Colorado Anschutz Medical Campus · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Loss of antimicrobial proteins such as REG3 family members compromises the integrity of the intestinal barrier. Here, we demonstrate that overproduction of REG3 proteins can also be detrimental by reducing a protective species in the microbiota. Patients with inflammatory bowel disease (IBD) experiencing flares displayed heightened levels of secreted REG3 proteins that mediated depletion of

Identifiers

PMID36778381
PMCPMC9915521
OpenAlexW4318677139

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.