Evidence map›Paper›PMID 36778380›Full record

ArticleResearch square2023

Lung infection by P. aeruginosa induces neuroinflammation and blood-brain barrier dysfunction in mice.

Nuria Villalba, Yonggang Ma, Sarah A Gahan, Aurelie Joly-Amado, Sam Spence, Xiaoyuan Yang, Kevin Nash, Sarah Y Yuan

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Nuria VillalbaUniversity of South Florida Morsani College of Medicine.
Yonggang MaUniversity of South Florida Morsani College of Medicine.
Sarah A GahanUniversity of South Florida Morsani College of Medicine.
Aurelie Joly-AmadoUniversity of South Florida Morsani College of Medicine.
Sam SpenceUniversity of South Florida Morsani College of Medicine.
Xiaoyuan YangUniversity of South Florida Morsani College of Medicine.
Kevin NashUniversity of South Florida Morsani College of Medicine.
Sarah Y YuanUniversity of South Florida Morsani College of Medicine.
University of South Florida · US

Funding

Vascular Barrier Leakage in InflammationR35HL150732 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI Sarah Y Yuan · 2020 to 2026
$6.2M
Endothelial glycocalyx shedding in septic injuryR01GM142110 · NIGMS · UNIVERSITY OF SOUTH FLORIDA · PI WU, MACK H, YUAN, SARAH Y · 2022 to 2025
$1.9M
NHLBI NIH HHS R35 HL150732NIGMS NIH HHS R01 GM142110
6 · The paper itself

Abstract

Background Severe lung infection can lead to brain dysfunction and neurobehavioral disorders. The mechanisms that regulate the lung-brain axis of inflammatory response to respiratory infection are incompletely understood. This study examined the effects of lung infection causing systemic and neuroinflammation as a potential mechanism contributing to blood-brain barrier (BBB) leakage and behavioral impairment. Methods Pneumonia was induced in adult C57BL/6 mice by intratracheal inoculation of

Identifiers

PMID36778380
PMCPMC9915779
OpenAlexW4318499671

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.