Evidence map›Paper›PMID 36778341›Full record

ArticlebioRxiv : the preprint server for biology2023

tRNA m

Sarah E Strassler, Isobel E Bowles, Aiswarya Krishnamohan, Hyejeong Kim, Catherine B Edgington, Emily G Kuiper, Clio J Hancock, Lindsay R Comstock, Jane E Jackman, Graeme L Conn

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Sarah E StrasslerDepartment of Biochemistry, Emory University School of Medicine, 1510 Clifton Road NE, Atlanta GA, 30322, USA.
Isobel E BowlesDepartment of Chemistry and Biochemistry, Center for RNA Biology and Ohio State Biochemistry Program, 484 W. 12 Avenue, Columbus, OH, 43210, USA.
Aiswarya KrishnamohanDepartment of Chemistry and Biochemistry, Center for RNA Biology and Ohio State Biochemistry Program, 484 W. 12 Avenue, Columbus, OH, 43210, USA.
Hyejeong KimDepartment of Chemistry and Biochemistry, Center for RNA Biology and Ohio State Biochemistry Program, 484 W. 12 Avenue, Columbus, OH, 43210, USA.
Catherine B EdgingtonDepartment of Chemistry and Biochemistry, Center for RNA Biology and Ohio State Biochemistry Program, 484 W. 12 Avenue, Columbus, OH, 43210, USA.
Emily G KuiperDepartment of Biochemistry, Emory University School of Medicine, 1510 Clifton Road NE, Atlanta GA, 30322, USA.
Clio J HancockDepartment of Biochemistry, Emory University School of Medicine, 1510 Clifton Road NE, Atlanta GA, 30322, USA.
Lindsay R ComstockDepartment of Chemistry, Wake Forest University, 1834 Wake Forest Road, Winston-Salem, NC 27106, USA.
Jane E JackmanDepartment of Chemistry and Biochemistry, Center for RNA Biology and Ohio State Biochemistry Program, 484 W. 12 Avenue, Columbus, OH, 43210, USA.
Graeme L ConnDepartment of Biochemistry, Emory University School of Medicine, 1510 Clifton Road NE, Atlanta GA, 30322, USA.
The Ohio State University · USEmory University · USWake Forest University · US

Funding

Mechanisms and Biological functions of SPOUT methyltransferasesR01GM130135 · NIGMS · OHIO STATE UNIVERSITY · PI Jane Elizabeth Jackman · 2018 to 2026
$2.3M
Typhoon FLA9500 Biomedical ImagerS10OD023582 · OD · OHIO STATE UNIVERSITY · PI JACKMAN, JANE ELIZABETH · 2017 to 2017
$144k
NIGMS NIH HHS R01 GM130135NIH HHS S10 OD023582
6 · The paper itself

Abstract

The methyltransferase Trm10 modifies a subset of tRNAs on the base N1 position of the 9th nucleotide in the tRNA core. Trm10 is conserved throughout Eukarya and Archaea, and mutations in the human gene (

Indexed as

RNA methylationRNA structureSHAPE RNA structure probingSPOUT methyltransferasesubstrate recognitiontransfer RNA (tRNA)

Identifiers

PMID36778341
PMCPMC9915607
OpenAlexW4319039685

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.