Evidence map›Paper›PMID 36778316›Full record

ArticleResearch square2023

Common laboratory diets differentially influence zebrafish gut microbiome's successional development and sensitivity to pathogen exposure.

Michael Sieler, Colleen Al-Samarrie, Kristin Kasschau, Zoltan Varga, Michael Kent, Thomas Sharpton

Open access · greenAbstract readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Michael SielerOregon State University.
Colleen Al-SamarrieOregon State University.
Kristin KasschauOregon State University.
Zoltan VargaUniversity of Oregon.
Michael KentOregon State University.
Thomas SharptonOregon State University.
Oregon State University · US

Funding

Zebrafish International Resource Center (ZIRC)P40OD011021 · OD · UNIVERSITY OF OREGON · PI Zoltan Marton Varga · 2012 to 2026
$36.0M
Control of Diseases in Zebrafish Research FacilitiesR24OD010998 · OD · OREGON STATE UNIVERSITY · PI KENT, MICHAEL LAWRENCE · 2012 to 2021
$3.0M
Impacts of Benzo[a]pyrene on Microbiome Development across Lifespan and Generations and the Behavioral ConsequencesR01ES030226 · NIEHS · OREGON STATE UNIVERSITY · PI SHARPTON, THOMAS JEFFERSON · 2019 to 2023
$2.1M
NIEHS NIH HHS R01 ES030226NIH HHS P40 OD011021NIH HHS R24 OD010998
6 · The paper itself

Abstract

Background: Despite the long-established importance of zebrafish Results: Our analysis finds that diet has a substantial impact on the composition of the gut microbiome in adult fish, and that diet also impacts the developmental variation in the gut microbiome. We further evaluated whether the 7-month-old fish microbiome compositions that result from dietary variation are differentially sensitive to infection by a common laboratory pathogen, Conclusions: Overall, our results indicate that diet drives the successional development of the gut microbiome as well as its sensitivity to exogenous exposure. Consequently, investigators should carefully consider the role of diet in their microbiome zebrafish investigations, especially when integrating results across studies that vary by diet.

Indexed as

DevelopmentDietGut microbiomeHusbandryInfectionMycobacterium chelonaeZebrafish

Identifiers

PMID36778316
PMCPMC9915791
OpenAlexW4318981205

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.