Evidence map›Paper›PMID 36778313›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Eric Yu, Lynne Krohn, Jennifer A Ruskey, Farnaz Asayesh, Dan Spiegelman, Zalak Shah, Ruth Chia, Isabelle Arnulf, Michele T M Hu, Jacques Y Montplaisir and 34 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

44 authors at 20 institutions in 9 countries.

Eric YuDepartment of Human Genetics, McGill University, Montréal, QC, Canada.
Lynne KrohnDepartment of Human Genetics, McGill University, Montréal, QC, Canada.
Jennifer A RuskeyThe Neuro (Montreal Neurological Institute-Hospital), McGill University, Montréal, QC, Canada.
Farnaz AsayeshThe Neuro (Montreal Neurological Institute-Hospital), McGill University, Montréal, QC, Canada.
Dan SpiegelmanThe Neuro (Montreal Neurological Institute-Hospital), McGill University, Montréal, QC, Canada.
Zalak ShahNeurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
Ruth ChiaNeuromuscular Diseases Research Section, National Institute on Aging, Bethesda, MD, USA.
Isabelle ArnulfSleep Disorders Unit, Pitié Salpêtrière Hospital, Paris Brain Institute and Sorbonne University, Paris, France.
Michele T M HuOxford Parkinson's Disease Centre (OPDC), University of Oxford, Oxford, United Kingdom.
Jacques Y MontplaisirCenter for Advanced Research in Sleep Medicine, Centre Intégré Universitaire de Santé et de Services Sociaux du Nord-de-l'île-de-Montréal - Hopital du Sacré-Coeur de Montréal, Montréal, QC, Canada.
Jean-François GagnonCenter for Advanced Research in Sleep Medicine, Centre Intégré Universitaire de Santé et de Services Sociaux du Nord-de-l'île-de-Montréal - Hopital du Sacré-Coeur de Montréal, Montréal, QC, Canada.
Alex DesautelsCenter for Advanced Research in Sleep Medicine, Centre Intégré Universitaire de Santé et de Services Sociaux du Nord-de-l'île-de-Montréal - Hopital du Sacré-Coeur de Montréal, Montréal, QC, Canada.
Yves DauvilliersNational Reference Center for Narcolepsy, Sleep Unit, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier, University of Montpellier, Inserm U1061, Montpellier, France.
Gian Luigi GigliClinical Neurology Unit, Department of Neurosciences, University Hospital of Udine, Udine, Italy.
Mariarosaria ValenteClinical Neurology Unit, Department of Neurosciences, University Hospital of Udine, Udine, Italy.
Francesco JanesClinical Neurology Unit, Department of Neurosciences, University Hospital of Udine, Udine, Italy.
Andrea BernardiniClinical Neurology Unit, Department of Neurosciences, University Hospital of Udine, Udine, Italy.
Birgit HöglSleep Disorders Clinic, Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Ambra StefaniSleep Disorders Clinic, Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Abubaker IbrahimSleep Disorders Clinic, Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Anna HeidbrederSleep Disorders Clinic, Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Karel SonkaDepartment of Neurology and Centre of Clinical Neuroscience, Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic.
Petr DusekDepartment of Neurology and Centre of Clinical Neuroscience, Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic.
David KemlinkDepartment of Neurology and Centre of Clinical Neuroscience, Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic.
Wolfgang OertelDepartment of Neurology, Philipps University, Marburg, Germany.
Annette JanzenDepartment of Neurology, Philipps University, Marburg, Germany.
Giuseppe PlazziDepartment of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio-Emilia, Modena, Italy.
Elena AntelmiNeurology Unit, Movement Disorders Division, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Michela FigorilliDepartment of Medical Sciences and Public Health, Sleep Disorder Research Center, University of Cagliari, Cagliari, Italy.
Monica PulighedduDepartment of Medical Sciences and Public Health, Sleep Disorder Research Center, University of Cagliari, Cagliari, Italy.
Brit MollenhauerParacelsus-Elena-Klinik, Kassel, Germany.
Claudia TrenkwalderParacelsus-Elena-Klinik, Kassel, Germany.
Friederike Sixel-DöringDepartment of Neurology, Philipps University, Marburg, Germany.
Valérie Cochen De CockSleep and Neurology Unit, Beau Soleil Clinic, Montpellier, France.
Luigi Ferini-StrambiDepartment of Neurological Sciences, Università Vita-Salute San Raffaele, Milan, Italy.
Femke DijkstraLaboratory for Sleep Disorders, St. Dimpna Regional Hospital, Geel, Belgium.
Mineke ViaeneLaboratory for Sleep Disorders, St. Dimpna Regional Hospital, Geel, Belgium.
Beatriz AbrilSleep disorder Unit, Carémeau Hospital, University Hospital of Nîmes, France.
Bradley F BoeveDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Guy A RouleauDepartment of Human Genetics, McGill University, Montréal, QC, Canada.
Ronald B PostumaThe Neuro (Montreal Neurological Institute-Hospital), McGill University, Montréal, QC, Canada.
Sonja W ScholzNeurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
International LBD Genomics Consortium
Ziv Gan-OrDepartment of Human Genetics, McGill University, Montréal, QC, Canada.
Montreal Neurological Institute and Hospital · CAInnsbruck Medical University · ATUniversity of Udine · ITCharles University · CZPhilipps University of Marburg · DEHôpital du Sacré-Cœur de Montréal · CAUniversitätsmedizin Göttingen · DEUniversity of Cagliari · ITAntwerp University Hospital · BEInserm · FRJohns Hopkins University · USMayo Clinic in Arizona · USNational Institute of Neurological Disorders and Stroke · USNational Institute on Aging · USSorbonne Université · FRUniversité de Montpellier · FRUniversité du Québec à Montréal · CAUniversity of Modena and Reggio Emilia · ITUniversity of Oxford · GBUniversity of Verona · IT

Funding

Genetic characterization of atypical parkinsonismZIANS003154 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI SCHOLZ, SONJA · 2016 to 2025
$15.4M
Intramural NIH HHS ZIA NS003154
6 · The paper itself

Abstract

Background and Objectives: Isolated/idiopathic REM sleep behavior disorder (iRBD) and Lewy body dementia (LBD) are synucleinopathies that have partial genetic overlap with Parkinson's disease (PD). Previous studies have shown that neuroinflammation plays a substantial role in these disorders. In PD, specific residues of the human leukocyte antigen ( Methods: We performed HLA imputation on iRBD genotyping data (1,072 patients and 9,505 controls) and LBD whole-genome sequencing (2,604 patients and 4,032 controls) using the multi-ethnic HLA reference panel v2 from the Michigan Imputation Server. Using logistic regression, we tested the association of HLA alleles, amino acids and haplotypes with disease susceptibility. We included age, sex and the top 10 principal components as covariates. We also performed an omnibus test to examine which HLA residue positions explain the most variance. Results: In iRBD, Discussion: This study identified an association between

Identifiers

PMID36778313
PMCPMC9915822
OpenAlexW4319038392

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.