Evidence map›Paper›PMID 36778287›Full record

ArticlebioRxiv : the preprint server for biology2023

Organism-Wide Analysis of Sepsis Reveals Mechanisms of Systemic Inflammation.

Michihiro Takahama, Ashwini Patil, Katherine Johnson, Denis Cipurko, Yoshimi Miki, Yoshitaka Taketomi, Peter Carbonetto, Madison Plaster, Gabriella Richey, Surya Pandey and 7 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. The design and engineering of synthetic genomes.Nature reviews. Genetics · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 2 countries.

Michihiro Takahama
Ashwini Patil
Katherine Johnson
Denis Cipurko
Yoshimi Miki
Yoshitaka Taketomi
Peter CarbonettoORCID 0000-0003-1144-6780
Madison Plaster
Gabriella Richey
Surya Pandey
Katerina Cheronis
Tatsuki Ueda
Adam Gruenbaum
Steven M Dudek
Matthew Stephens
Makoto Murakami
Nicolas ChevrierORCID 0000-0002-9667-4506
University of Chicago · USTokyo Metropolitan Institute of Medical Science · JPJapan Agency for Medical Research and Development · JPUniversity of Illinois Chicago · US

Funding

ULTRASTRUCTURE AND CYTOMORPHOLOGY COREP30DK042086 · NIDDK · UNIVERSITY OF CHICAGO · PI LIU, CAMBRIAN YANGSHAO · 1990 to 2025
$29.8M
NIDDK NIH HHS P30 DK042086
6 · The paper itself

Abstract

Sepsis is a systemic response to infection with life-threatening consequences. Our understanding of the impact of sepsis across organs of the body is rudimentary. Here, using mouse models of sepsis, we generate a dynamic, organism-wide map of the pathogenesis of the disease, revealing the spatiotemporal patterns of the effects of sepsis across tissues. These data revealed two interorgan mechanisms key in sepsis. First, we discover a simplifying principle in the systemic behavior of the cytokine network during sepsis, whereby a hierarchical cytokine circuit arising from the pairwise effects of TNF plus IL-18, IFN-γ, or IL-1β explains half of all the cellular effects of sepsis on 195 cell types across 9 organs. Second, we find that the secreted phospholipase PLA2G5 mediates hemolysis in blood, contributing to organ failure during sepsis. These results provide fundamental insights to help build a unifying mechanistic framework for the pathophysiological effects of sepsis on the body.

Identifiers

PMID36778287
PMCPMC9915512
OpenAlexW4318954403

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.