Evidence map›Paper›PMID 36778282›Full record

ArticlebioRxiv : the preprint server for biology2023

Quercetin selectively reduces expanded repeat RNA levels in models of myotonic dystrophy.

Subodh K Mishra, Sawyer M Hicks, Jesus A Frias, Sweta Vangaveti, Masayuki Nakamori, John D Cleary, Kaalak Reddy, J Andrew Berglund

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Subodh K MishraThe RNA Institute, University at Albany, State University of New York, Albany, NY 12222, USA.
Sawyer M HicksThe RNA Institute, University at Albany, State University of New York, Albany, NY 12222, USA.
Jesus A FriasThe RNA Institute, University at Albany, State University of New York, Albany, NY 12222, USA.
Sweta VangavetiThe RNA Institute, University at Albany, State University of New York, Albany, NY 12222, USA.
Masayuki NakamoriDepartment of Neurology, Osaka University Graduate School of Medicine; Osaka, Japan, 565-0871.
John D ClearyThe RNA Institute, University at Albany, State University of New York, Albany, NY 12222, USA.
Kaalak ReddyThe RNA Institute, University at Albany, State University of New York, Albany, NY 12222, USA.
J Andrew BerglundThe RNA Institute, University at Albany, State University of New York, Albany, NY 12222, USA.
Albany State University · USOsaka City University · JP

Funding

Senator Paul D. Wellstone Muscular Dystrophy Specialized Research CenterP50NS048843 · NINDS · UNIVERSITY OF ROCHESTER · PI THORNTON, CHARLES A · 2018 to 2022
$7.1M
Identifying the RNA Splicing and Gene Expression Changes that Cause Congenital Myotonic Dystrophy (Renewal)R01NS104010 · NINDS · VIRGINIA COMMONWEALTH UNIVERSITY · PI Nicholas Elwood Johnson · 2018 to 2026
$4.4M
Design, Synthesis and Efficacy of New Small Molecule Therapeutics to Impede Myotonic DystrophyR01NS120485 · NINDS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI Andrew Berglund, Masayuki Nakamori · 2022 to 2026
$2.7M
RNA Science and Technology in Health and DiseaseT32GM132066 · NIGMS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI Thomas J Begley · 2019 to 2026
$1.8M
NIGMS NIH HHS T32 GM132066NINDS NIH HHS P50 NS048843NINDS NIH HHS R01 NS104010NINDS NIH HHS R01 NS120485
6 · The paper itself

Abstract

Myotonic dystrophy is a multisystemic neuromuscular disease caused by either a CTG repeat expansion in

Identifiers

PMID36778282
PMCPMC9915578
OpenAlexW4319162149

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.