Evidence map›Paper›PMID 36778273›Full record

ArticleResearch square2023

Structural Basis for Self-Discrimination by Neoantigen-Specific TCRs.

John P Finnigan, Jenna H Newman, Yury Patskovsky, Larysa Patskovska, Andrew S Ishizuka, Geoffrey M Lynn, Robert A Seder, Michelle Krogsgaard, Nina Bhardwaj

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

John P FinniganIcahn School of Medicine at Mount Sinai; One Gustave L. Levy Pl., New York, NY.
Jenna H NewmanIcahn School of Medicine at Mount Sinai; One Gustave L. Levy Pl., New York, NY.
Yury PatskovskyDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
Larysa PatskovskaDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
Andrew S IshizukaVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Geoffrey M LynnVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Robert A SederVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Michelle KrogsgaardDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
Nina BhardwajIcahn School of Medicine at Mount Sinai; One Gustave L. Levy Pl., New York, NY.
Icahn School of Medicine at Mount Sinai · USNew York University · USVaccitech (United Kingdom) · GBNational Institute of Allergy and Infectious Diseases · US

Funding

Project 4P50CA225450 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KIRCHHOFF, TOMAS · 2019 to 2025
$12.5M
TRAINING PROGRAM IN CANCER THERAPYT32CA078207 · NCI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI James J Manfredi · 1999 to 2026
$11.6M
Translational Immunology Training ProgramT32AI078892 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Karen Leigh Edelblum, SERGIO A. LIRA · 2008 to 2026
$4.5M
Mechanisms of impaired T-cell mechanosensing of melanoma antigensU01CA214354 · NCI · GEORGIA INSTITUTE OF TECHNOLOGY · PI KROGSGAARD, MICHELLE, ZHU, CHENG · 2017 to 2021
$3.9M
T-cell intrinsic mechanisms of resistance to PD-1 checkpoint blockadeR01CA243486 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KROGSGAARD, MICHELLE, ZHU, CHENG · 2020 to 2024
$3.5M
NK cell exhaustion in metastatic melanomaR01CA201189 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BHARDWAJ, NINA · 2016 to 2020
$2.1M
Mechanisms of initiation of T-cell signaling by the TCR-CD3 complexR01GM124489 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KROGSGAARD, MICHELLE · 2018 to 2021
$2.1M
Visualizing ligand-induced signal propagation in the TCR-signaling complexR01GM085586 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KROGSGAARD, MICHELLE · 2008 to 2014
$1.5M
NCI NIH HHS P50 CA225450NCI NIH HHS R01 CA201189NCI NIH HHS R01 CA243486NCI NIH HHS T32 CA078207NCI NIH HHS U01 CA214354NIAID NIH HHS T32 AI078892NIGMS NIH HHS R01 GM124489
6 · The paper itself

Abstract

Physical interactions between T cell receptors (TCRs) and mutation-derived tumour neoantigens (neoAg) presented by major histocompatibility class-I (MHC-I) enable sensitive and specific cytolysis of tumour cells. Adoptive transfer of neoAg-reactive T cells in patients is correlated with response to immunotherapy; however, the structural and cellular mechanisms of neoAg recognition remain poorly understood. We have identified multiple cognate neoAg:TCRs from B16F10, a common murine implantable tumour model of melanoma. We identified a high affinity TCR targeting H2-D

Indexed as

cancerimmunologyneoantigenstructureTCR

Identifiers

PMID36778273
PMCPMC9915759
OpenAlexW4318707891

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.