Evidence map›Paper›PMID 36778268›Full record

ArticlebioRxiv : the preprint server for biology2023

EMBER multi-dimensional spectral microscopy enables quantitative determination of disease- and cell-specific amyloid strains.

Hyunjun Yang, Peng Yuan, Yibing Wu, Marie Shi, Christoffer D Caro, Atsushi Tengeiji, Shigeo Yamanoi, Masahiro Inoue, William F DeGrado, Carlo Condello

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Hyunjun YangInstitute for Neurodegenerative Diseases, University of California, San Francisco, CA 94143.
Peng YuanInstitute for Neurodegenerative Diseases, University of California, San Francisco, CA 94143.
Yibing WuDepartment of Pharmaceutical Chemistry, Cardiovascular Research Institute, University of California, San Francisco, CA 94158.
Marie ShiInstitute for Neurodegenerative Diseases, University of California, San Francisco, CA 94143.
Christoffer D CaroInstitute for Neurodegenerative Diseases, University of California, San Francisco, CA 94143.
Atsushi TengeijiDaiichi Sankyo Co. Ltd, Tokyo, Japan.
Shigeo YamanoiDaiichi Sankyo Co. Ltd, Tokyo, Japan.
Masahiro InoueDaiichi Sankyo Co. Ltd, Tokyo, Japan.
William F DeGradoInstitute for Neurodegenerative Diseases, University of California, San Francisco, CA 94143.
Carlo CondelloInstitute for Neurodegenerative Diseases, University of California, San Francisco, CA 94143.

Funding

TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
VIRAL DEGENERATIVE DEMENTING DISEASE IN AGING (SUPP)P01AG002132 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SALI, ANDREJ · 1985 to 2024
$51.7M
THE ROLE OF ADVANCED CAA IN ALZHEIMER'S DEMENTIAP50AG005134 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI HYMAN, BRADLEY T. · 1985 to 2018
$42.1M
The Alzheimer's Disease Research Center at the University of California, IrvineP30AG066519 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Mathew Mark Blurton-Jones · 2020 to 2026
$27.9M
PrPSc SPECIFIC INTERACTION WITH NOVEL PrP-Fc FUSION PROTEINSP50AG023501 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MILLER, BRUCE L · 2004 to 2018
$27.1M
Relationships between conformational strains of tau and amyloid-beta, TREM2 and APOE variants, and phenotypic variations of Alzheimer's DiseaseRF1AG061874 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CONDELLO, CARLO L, DEGRADO, WILLIAM · 2018 to 2018
$2.0M
NIA NIH HHS P01 AG002132NIA NIH HHS P01 AG019724NIA NIH HHS P30 AG066519NIA NIH HHS P50 AG005134NIA NIH HHS P50 AG023501NIA NIH HHS RF1 AG061874
6 · The paper itself

Abstract

In neurodegenerative diseases proteins fold into amyloid structures with distinct conformations (strains) that are characteristic of different diseases. However, there is a need to rapidly identify amyloid conformations Significance: In neurodegenerative diseases proteins fold into amyloid structures with distinct conformations (strains) that are characteristic of different diseases. There is a need to rapidly identify these amyloid conformations

Identifiers

PMID36778268
PMCPMC9915571

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.