Evidence map›Paper›PMID 36778243›Full record

ArticleResearch square2023

Astrocyte reactivity influences the association of amyloid-β and tau biomarkers in preclinical Alzheimer's disease.

Tharick Pascoal, Bruna Bellaver, Guilherme Povala, Pamela Ferreira, João Pedro Ferrari-Souza, Douglas Leffa, Firoza Lussier, Andrea Benedet, Nicholas Ashton, Gallen Triana-Baltzerz and 23 more

Open access · greenAbstract readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

33 authors at 7 institutions in 5 countries.

Tharick PascoalUniversity of Pittsburgh.
Bruna BellaverUniversity of Pittsburgh.ORCID 0000-0002-2212-3373
Guilherme PovalaUniversity of Pittsburgh.
Pamela FerreiraUniversity of Pittsburgh.
João Pedro Ferrari-SouzaUniversidade Federal do Rio Grande do Sul.
Douglas LeffaUniversity of Pittsburgh.
Firoza LussierUniversity of Pittsburgh.
Andrea BenedetDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Mölndal, Sweden.
Nicholas AshtonDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Mölndal, Sweden.
Gallen Triana-BaltzerzJanssen Research and Development.
Hartmuth KolbzhJanssen Research and Development.
Cèile TissotMcGill University.ORCID 0000-0003-2711-3833
Joseph TherriaultMcGill University.ORCID 0000-0002-7826-4781
Stijn ServaesMcGill University.
Jenna StevensonMcGill University.
Nesrine RahmouniMcGill University.
Oscar LopezDepartments of Neurology and Psychiatry, University of Pittsburgh.ORCID 0000-0002-8546-8256
Dana TudorascuUniversity of Pittsburgh.
Victor VillemagneUniversity of Pittsburgh.
Milos IkonomovicUniversity of Pittsburgh.
Serge GauthierMcGill University.
Eduardo ZimmerUniversidade Federal do Rio Grande do Sul.
Henrik ZetterbergUniversity of Gothenburg.ORCID 0000-0003-3930-4354
Kaj BlennowUniversity of Gothenburg.ORCID 0000-0002-1890-4193
Howard AizensteinUniversity of Pittsburgh Medical Center.
William KlunkUniversity of Pittsburgh.
Beth SnitzUniversity of Pittsburgh.
Pauline MakiUniversity of Illinois.
Rebecca ThurstonUniversity of Pittsburgh.ORCID 0000-0001-6580-1202
Ann CohenUniversity of Pittsburgh.
Mary GanguliUniversity of Pittsburgh.
Thomas KarikariUniversity of Pittsburgh.
Pedro Rosa-NetoMcGill University.ORCID 0000-0001-9116-1376
University of Pittsburgh · USMcGill University · CAUniversity of Gothenburg · SEJanssen (Belgium) · BEUniversidade Federal do Rio Grande do Sul · BRUniversity of Illinois System · USUniversity of Pittsburgh Medical Center · US

Funding

Longitudinal multicenter head-to-head harmonization of tau PET tracersR01AG073267 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BAKER, SUZANNE L, PASCOAL, THARICK · 2021 to 2025
$41.1M
Mild Cognitive Impairment: A Prospective Community StudyR37AG023651 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Carmen Andreescu, MARY GANGULI · 2021 to 2026
$18.2M
Menopausal Vasomotor Symptoms and Brain Aging in WomenRF1AG053504 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MAKI, PAULINE M, THURSTON, REBECCA C · 2016 to 2019
$4.1M
Head-to-head comparisons of high-performance plasma phospho-tau epitopes for the detection of Alzheimer's diseaseR01AG075336 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Tharick Pascoal · 2022 to 2026
$3.7M
Mechanisms linking hot flashes to cardiovascular riskR01HL105647 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI THURSTON, REBECCA C · 2011 to 2015
$3.2M
Interdisciplinary Mentoring and Research in Womens Cardiovascular HealthK24HL123565 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI THURSTON, REBECCA C · 2014 to 2023
$1.0M
NHLBI NIH HHS K24 HL123565NHLBI NIH HHS R01 HL105647NIA NIH HHS R01 AG073267NIA NIH HHS R01 AG075336NIA NIH HHS R37 AG023651NIA NIH HHS RF1 AG053504
6 · The paper itself

Abstract

An unresolved question for the understanding of Alzheimer's disease (AD) pathophysiology is why a significant percentage of amyloid β (Aβ)-positive cognitively unimpaired (CU) individuals do not develop detectable downstream tau pathology and, consequently, clinical deterioration.

Identifiers

PMID36778243
PMCPMC9915798
OpenAlexW4318763942

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.