ArticleCell genomics2022
Type 1 diabetes risk genes mediate pancreatic beta cell survival in response to proinflammatory cytokines.
Open access · goldAbstract read
In one paragraph
Article in Cell genomics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 27 citations in OpenAlex.
- Shared non-HLA genetic architecture across diverse ancestries links insulin secretion and resistance to type 1 diabetes.Diabetologia · 2026Article
- Oxidative Stress Biomarkers in Pediatric and Early-Stage Type 1 Diabetes: Toward Redox Phenotyping.Antioxidants (Basel, Switzerland) · 2026Review
- Tetherin enforces an immunometabolic checkpoint that coordinates glycolytic and interferon signaling in adipocytes.bioRxiv : the preprint server for biology · 2026Article
- A surviving beta cell subpopulation enriched in patients with T1D.bioRxiv : the preprint server for biology · 2026Article
- A mitochondrial ROS-dependent antiviral response promotes β cell resilience and is diminished in donors with type 1 diabetes.Science translational medicine · 2026Article
- Genetic association and machine learning improve the prediction of type 1 diabetes risk.Nature genetics · 2026Article
- Functional genomics reveals mediators of beta cell survival in ER stress and type 2 diabetes risk.bioRxiv : the preprint server for biology · 2026Article
- PTPN2 deficiency amplifies inflammatory signalling and impairs functional maturation of human stem cell-derived islets.Stem cell research & therapy · 2026Article
- From Human to Mouse and Back Again: Genetic and Genomic Ta(i)les of Islet Dysfunction in Type 2 Diabetes.Annual review of genetics · 2025Review
- Single-cell multiome and spatial profiling reveals pancreas cell type-specific gene regulatory programs of type 1 diabetes progression.Science advances · 2025Article
- Diabetes mellitus polygenic risk scores: heterogeneity and clinical translation.Nature reviews. Endocrinology · 2025Review
- Autoreactive T Cells and Cytokine Stress Drive β-Cell Senescence Entry and Accumulation in Type 1 Diabetes.Diabetes · 2025Article
- Integrative single-cell multi-omics profiling of human pancreatic islets identifies T1D-associated genes and regulatory signals.Cell reports · 2025Article
- Mitochondrial-encoded peptide MOTS-c prevents pancreatic islet cell senescence to delay diabetes.Experimental & molecular medicine · 2025Article
- DOC2b enrichment mitigates proinflammatory cytokine-induced CXCL10 expression by attenuating IKKβ and STAT-1 signaling in human islets.Metabolism: clinical and experimental · 2025Article
- Enhanced dynorphin expression and secretion in pancreatic beta-cells under hyperglycemic conditions.Molecular metabolism · 2025Article
- Genetic Discovery and Risk Prediction for Type 1 Diabetes in Individuals Without High-Risk HLA-DR3/DR4 Haplotypes.Diabetes care · 2025Article
- Revealing the biological features of the axolotl pancreas as a new research model.Frontiers in cell and developmental biology · 2025Article
- Mini review: Interleukin-32 as a key mediator of type 1 diabetes pathogenesis.Frontiers in immunology · 2025Review
- Linking epigenetic mechanisms of T cell dysfunction with pathophysiology of type 1 diabetes mellitus.Frontiers in immunology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 3 institutions in 6 countries.
Paola BenaglioDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
Han ZhuDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
Mei-Lin OkinoDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
Jian YanLudwig Institute for Cancer Research, La Jolla, CA, USA.
Ruth ElgamalDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
Naoki NariaiDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
Elisha BeebeDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
Katha KorgaonkarDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
Yunjiang QiuDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Margaret K R DonovanDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
Joshua ChiouDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
Gaowei WangDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
Jacklyn NewsomeDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
Jaspreet KaurDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
Michael MillerCenter for Epigenomics, University of California, San Diego, La Jolla, CA, USA.
Sebastian PreisslCenter for Epigenomics, University of California, San Diego, La Jolla, CA, USA.
Sierra CorbanDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
Anthony AylwardDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
Jussi TaipaleDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna, Sweden.
Bing RenDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Kelly A FrazerDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
Maike SanderDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
Kyle J GaultonDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
University of California San Diego · USCity University of Hong Kong · HKUniversity of Helsinki · FI
Funding
Functional Analysis of T2D Associated Non-coding SNPsU01DK105541 · NIDDK · LUDWIG INSTITUTE FOR CANCER RES LTD · PI FRAZER, KELLY A, REN, BING · 2015 to 2019
$4.6MGenetic mechanisms of type 1 diabetes risk in stress-induced pancreatic isletsR01DK122607 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GAULTON, KYLE JEFFRIE · 2019 to 2022
$4.4MFine-mapping and functional analysis of T1D-associated variantsDP3DK112155 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FRAZER, KELLY A, SANDER, MAIKE · 2016 to 2016
$3.3MSingle cell analysis of the human pancreas in type 1 diabetesU01DK120429 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GAULTON, KYLE JEFFRIE, SANDER, MAIKE · 2018 to 2021
$3.1MUC San Diego Genetics Training ProgramT32GM145427 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BRUCE A HAMILTON · 2022 to 2026
$2.6MNIDDK NIH HHS DP3 DK112155NIDDK NIH HHS R01 DK122607NIDDK NIH HHS U01 DK105541NIDDK NIH HHS U01 DK120429NIGMS NIH HHS T32 GM145427
Abstract
We combined functional genomics and human genetics to investigate processes that affect type 1 diabetes (T1D) risk by mediating beta cell survival in response to proinflammatory cytokines. We mapped 38,931 cytokine-responsive candidate
Indexed as
3D chromatin interactionsaccessible chromatinbeta cellCRISPR screenfunctional genomicsgene expressionhigh-throughput reporter assayhuman geneticsproinflammatory cytokinestype 1 diabetes
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.