Evidence map›Paper›PMID 36778002›Full record

ArticleFrontiers in pharmacology2023

Characterizing metabolic drivers of

Katelyn A Bustin, Arwa Abbas, Xie Wang, Michael C Abt, Joseph P Zackular, Megan L Matthews

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Unravelling three-way interactions betweenJournal of medical microbiology · 2025
    Review
  4. mSphere · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Katelyn A BustinDepartment of Chemistry, University of Pennsylvania, Philadelphia, PA, United States.
Arwa AbbasDivision of Protective Immunity, Children's Hospital of Pennsylvania, Philadelphia, PA, United States.
Xie WangDepartment of Chemistry, University of Pennsylvania, Philadelphia, PA, United States.
Michael C AbtDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Joseph P ZackularDivision of Protective Immunity, Children's Hospital of Pennsylvania, Philadelphia, PA, United States.
Megan L MatthewsDepartment of Chemistry, University of Pennsylvania, Philadelphia, PA, United States.
University of Pennsylvania · USChildren's Hospital of Philadelphia · US

Funding

TRANSGENIC AND CHIMERIC MOUSE COREP30DK050306 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI REBECCA G WELLS · 1997 to 2026
$32.5M
Predoctoral Training at the Chemistry-Biology InterfaceT32GM071339 · NIGMS · WISTAR INSTITUTE · PI MARMORSTEIN, RONEN, SPEICHER, DAVID W. · 2005 to 2019
$3.2M
Molecular interactions in the gut microbiota during early life colonization and perturbationR35GM138369 · NIGMS · CHILDREN'S HOSP OF PHILADELPHIA · PI Joseph Paul Zackular · 2020 to 2026
$2.7M
MAOI-inspired activity probes to translate epigenetics and genetics into drugsDP1DA051620 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI MATTHEWS, MEGAN L · 2020 to 2024
$2.5M
Investigating Immune-Microbiome interactions during treatment of Clostridioides difficile with fecal microbiome transplantationR01AI158830 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ABT, MICHAEL C. · 2021 to 2025
$2.4M
Immune regulation of the transcriptional and spatial profile of Clostridioides difficileR21AI164385 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ABT, MICHAEL C. · 2021 to 2022
$447k
NIAID NIH HHS R01 AI158830NIAID NIH HHS R21 AI164385NIDA NIH HHS DP1 DA051620NIDDK NIH HHS P30 DK050306NIGMS NIH HHS R35 GM138369NIGMS NIH HHS T32 GM071339
6 · The paper itself

Abstract

Many enzymes require post-translational modifications or cofactor machinery for primary function. As these catalytically essential moieties are highly regulated, they act as dual sensors and chemical handles for context-dependent metabolic activity.

Indexed as

ABPPClostridioides difficile infectioncofactordruggable modalityhydrazine pharmacophoreStickland fermentation

Identifiers

PMID36778002
PMCPMC9908766
OpenAlexW4318046802

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.