ArticleCell genomics2022
Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease.
Open access · goldAbstract read
In one paragraph
Article in Cell genomics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 315 papers, 16 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
315citing papers in PubMed, 16 pooled it
68.6field-weighted citation impact, top 1% of its field
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Who cites it
315 citing papers in PubMed, 16 syntheses or guidelines pooled it, 384 citations in OpenAlex.
- Assessing the causal effects of environmental tobacco smoke exposure: a meta-analytic Mendelian randomization study.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026Pooled it
- Genetic drivers of etiologic heterogeneity in thyroid cancer.Nature communications · 2026Pooled it
- Pooled it
- Pooled it
- Genome-wide association analyses of autoimmune hypothyroidism reveal autoimmune and thyroid-specific contributions and an inverse relationship with cancer risk.Nature genetics · 2026Pooled it
- Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases.Nature genetics · 2026Pooled it
- Genetic and environmental risk factors of asthma: a narrative review.Frontiers in immunology · 2026Pooled it
- Genomic dissection of methane emission traits in cattle: A meta-GWAS and heritability analysis across populations.PloS one · 2026Pooled it
- Genome-wide analysis of heart failure yields insights into disease heterogeneity and enables prognostic prediction in the Japanese population.Nature communications · 2025Pooled it
- Genome-wide analysis identifies susceptibility loci for heart failure and nonischemic cardiomyopathy subtype in the East Asian populations.PLoS genetics · 2025Pooled it
- Pan-UK Biobank genome-wide association analyses enhance discovery and resolution of ancestry-enriched effects.Nature genetics · 2025Pooled it
- Integrative bioinformatics frameworks for abdominal aortic aneurysm using GWAS meta-analysis, biological network construction, and structural modeling.Scientific reports · 2025Pooled it
- Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes.Nature genetics · 2025Pooled it
- GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets.Nature communications · 2025Pooled it
- Multi-Ancestry Mendelian Randomization Reveals Lipid-Associated Genetic Risk Factors for COPD.International journal of chronic obstructive pulmonary disease · 2025Pooled it
- metaGE: Investigating genotype x environment interactions through GWAS meta-analysis.PLoS genetics · 2025Pooled it
- GWAS data selection matters in MR: comment on "causal relationship between mental illness and venous thromboembolism: a mendelian randomization study".European archives of psychiatry and clinical neuroscience · 2026Article
- Proteome-wide genetic analyses identify ASGR1 as a potential biomarker linking smoking with ischemic heart disease.Nature cardiovascular research · 2026Article
- All of Us diversity and scale yield context-dependent improvements in polygenic prediction.Nature genetics · 2026Article
- SPLENDID incorporates continuous genetic ancestry in biobank-scale data to improve polygenic risk prediction across diverse populations.Nature methods · 2026Article
255 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
176 authors at 20 institutions in 19 countries.
Wei ZhouAnalytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Masahiro KanaiAnalytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Kuan-Han H WuDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Humaira RasheedK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Kristin TsuoAnalytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Jibril B HirboDepartment of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Ying WangAnalytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Arjun BhattacharyaDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Huiling ZhaoMRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Bristol, UK.
Shinichi NambaDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan.
Ida SurakkaDepartment of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.
Brooke N WolfordDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Valeria Lo FaroUniversity of Groningen, UMCG, Department of Ophthalmology, Groningen, the Netherlands.
Esteban A Lopera-MayaUniversity of Groningen, UMCG, Department of Genetics, Groningen, the Netherlands.
Kristi LällEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Marie-Julie FavéOntario Institute for Cancer Research, Toronto, ON, Canada.
Juulia J PartanenInstitute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
Sinéad B ChapmanStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Juha KarjalainenAnalytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Mitja KurkiAnalytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Mutaamba MaashaAnalytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Ben M BrumptonK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Sameer ChavanUniversity of Colorado - Anschutz Medical Campus, Aurora, CO, USA.
Tzu-Ting ChenCenter for Neuropsychiatric Research, National Health Research Institutes, Miaoli, Taiwan.
Michelle DayaUniversity of Colorado - Anschutz Medical Campus, Aurora, CO, USA.
Yi DingDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Yen-Chen A FengDivision of Biostatistics, Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
Lindsay A GuareDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Christopher R GignouxUniversity of Colorado - Anschutz Medical Campus, Aurora, CO, USA.
Sarah E GrahamDepartment of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.
Whitney E HornsbyDepartment of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.
Nathan IngoldQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Said I IsmailQatar Genome Program, Qatar Foundation Research, Development and Innovation, Qatar Foundation, Doha, Qatar.
Ruth JohnsonDepartment of Computer Science, University of California, Los Angeles, Los Angeles, CA, USA.
Triin LaiskEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Kuang LinNuffield Department of Population Health, University of Oxford, Oxford, UK.
Jun LvDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China.
Iona Y MillwoodNuffield Department of Population Health, University of Oxford, Oxford, UK.
Sonia Moreno-GrauGalatea Bio, Inc., Hialeah, FL, USA.
Kisung NamGraduate School of Data Science, Seoul National University, Seoul, South Korea.
Priit PaltaEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Anita PanditDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Michael H PreussThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Chadi SaadQatar Genome Program, Qatar Foundation Research, Development and Innovation, Qatar Foundation, Doha, Qatar.
Shefali Setia-VermaDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Unnur ThorsteinsdottirdeCODE Genetics/Amgen, Inc., 101 Reykjavik, Iceland.
Jasmina UzunovicOntario Institute for Cancer Research, Toronto, ON, Canada.
Anurag VermaDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Matthew ZawistowskiDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Xue ZhongDepartment of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Nahla AfifiQatar Biobank for Medical Research, Qatar Foundation for Education, Science, and Community, Doha, Qatar.
Kawthar M Al-DabhaniQatar Biobank for Medical Research, Qatar Foundation for Education, Science, and Community, Doha, Qatar.
Asma Al ThaniQatar Biobank for Medical Research, Qatar Foundation for Education, Science, and Community, Doha, Qatar.
Yuki BradfordDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Archie CampbellCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Kristy CrooksUniversity of Colorado - Anschutz Medical Campus, Aurora, CO, USA.
Geertruida H de BockDepartment of Epidemiology, University Medical Center Groningen, Groningen, the Netherlands.
Scott M DamrauerDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Nicholas J DouvilleDepartment of Anesthesiology, Michigan Medicine, Ann Arbor, MI, USA.
Sarah FinerWolfson Institute of Population Health, Queen Mary University of London, London, UK.
Lars G FritscheDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Eleni FthenouQatar Biobank for Medical Research, Qatar Foundation for Education, Science, and Community, Doha, Qatar.
Gilberto Gonzalez-ArroyoGalatea Bio, Inc., Hialeah, FL, USA.
Christopher J GriffithsWolfson Institute of Population Health, Queen Mary University of London, London, UK.
Yu GuoChinese Academy of Medical Sciences, Beijing, China.
Karen A HuntBlizard Institute, Queen Mary University of London, London, UK.
Alexander IoannidisGalatea Bio, Inc., Hialeah, FL, USA.
Nomdo M JansoniusUniversity of Groningen, UMCG, Department of Ophthalmology, Groningen, the Netherlands.
Takahiro KonumaDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan.
Ming Ta Michael LeeGalatea Bio, Inc., Hialeah, FL, USA.
Arturo Lopez-PinedaGalatea Bio, Inc., Hialeah, FL, USA.
Yuta MatsudaGenomelink, Inc., Berkeley, CA, USA.
Riccardo E MarioniCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Babak MoatamedGalatea Bio, Inc., Hialeah, FL, USA.
Marco A Nava-AguilarGalatea Bio, Inc., Hialeah, FL, USA.
Kensuke NumakuraGenomelink, Inc., Berkeley, CA, USA.
Snehal PatilDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Nicholas RafaelsUniversity of Colorado - Anschutz Medical Campus, Aurora, CO, USA.
Anne RichmondMedical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Agustin Rojas-MuñozGalatea Bio, Inc., Hialeah, FL, USA.
Jonathan A ShorttUniversity of Colorado - Anschutz Medical Campus, Aurora, CO, USA.
Peter StraubDepartment of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Ran TaoVanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.
Brett VanderwerffDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Manvi VernekarGenomelink, Inc., Berkeley, CA, USA.
Yogasudha VeturiDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Kathleen C BarnesUniversity of Colorado - Anschutz Medical Campus, Aurora, CO, USA.
Marike BoezenDepartment of Epidemiology, University Medical Center Groningen, Groningen, the Netherlands.
Zhengming ChenNuffield Department of Population Health, University of Oxford, Oxford, UK.
Chia-Yen ChenBiogen, Cambridge, MA, USA.
Judy ChoThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
George Davey SmithMRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Bristol, UK.
Hilary K FinucaneAnalytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Lude FrankeUniversity of Groningen, UMCG, Department of Genetics, Groningen, the Netherlands.
Eric R GamazonDepartment of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Andrea GannaAnalytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Tom R GauntMRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Bristol, UK.
Tian GePsychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Hailiang HuangAnalytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Jennifer HuffmanCentre for Population Genomics, VA Boston Healthcare System, Boston, MA, USA.
Nicholas KatsanisGalatea Bio, Inc., Hialeah, FL, USA.
Jukka T KoskelaInstitute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
Clara LajonchereInstitute of Precision Health, University of California, Los Angeles, Los Angeles, CA, USA.
Matthew H LawQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Liming LiDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China.
Cecilia M LindgrenBig Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.
Ruth J F LoosThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Stuart MacGregorQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Koichi MatsudaDepartment of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
Catherine M OlsenQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
David J PorteousCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Jordan A ShavitUniversity of Michigan, Department of Pediatrics, Ann Arbor, MI 48109, USA.
Harold SniederDepartment of Epidemiology, University Medical Center Groningen, Groningen, the Netherlands.
Tomohiro TakanoGenomelink, Inc., Berkeley, CA, USA.
Richard C TrembathSchool of Basic and Medical Biosciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
Judith M VonkDepartment of Epidemiology, University Medical Center Groningen, Groningen, the Netherlands.
David C WhitemanQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Stephen J WicksUniversity of Colorado - Anschutz Medical Campus, Aurora, CO, USA.
Cisca WijmengaUniversity of Groningen, UMCG, Department of Genetics, Groningen, the Netherlands.
John WrightBradford Institute for Health Research, Bradford Teaching Hospitals National Health Service (NHS) Foundation Trust, Bradford, UK.
Jie ZhengMRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Bristol, UK.
Xiang ZhouDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Philip AwadallaOntario Institute for Cancer Research, Toronto, ON, Canada.
Michael BoehnkeDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Carlos D BustamanteGalatea Bio, Inc., Hialeah, FL, USA.
Nancy J CoxDepartment of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Segun FatumoThe African Computational Genomics (TACG) Research Group, MRC/UVRI and LSHTM, Entebbe, Uganda.
Daniel H GeschwindInstitute of Precision Health, University of California, Los Angeles, Los Angeles, CA, USA.
Caroline HaywardMedical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Kristian HveemK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Eimear E KennyInstitute for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Seunggeun LeeGraduate School of Data Science, Seoul National University, Seoul, South Korea.
Yen-Feng LinCenter for Neuropsychiatric Research, National Health Research Institutes, Miaoli, Taiwan.
Hamdi MbarekQatar Genome Program, Qatar Foundation Research, Development and Innovation, Qatar Foundation, Doha, Qatar.
Reedik MägiEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Hilary C MartinHuman Genetics Programme, Wellcome Sanger Institute, Hinxton, UK.
Sarah E MedlandQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Yukinori OkadaDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan.
Aarno V PalotieAnalytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Bogdan PasaniucDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Daniel J RaderDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Marylyn D RitchieDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Serena SannaUniversity of Groningen, UMCG, Department of Genetics, Groningen, the Netherlands.
Jordan W SmollerPsychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Kari StefanssondeCODE Genetics/Amgen, Inc., 101 Reykjavik, Iceland.
David A van HeelBlizard Institute, Queen Mary University of London, London, UK.
Robin G WaltersNuffield Department of Population Health, University of Oxford, Oxford, UK.
Sebastian ZöllnerDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Biobank of the Americas
Biobank Japan Project
BioMe
BioVU
CanPath - Ontario Health Study
China Kadoorie Biobank Collaborative Group
Colorado Center for Personalized Medicine
deCODE Genetics
Estonian Biobank
FinnGen
Generation Scotland
Genes & Health Research Team
LifeLines
Mass General Brigham Biobank
Michigan Genomics Initiative
National Biobank of Korea
Penn Medicine BioBank
Qatar Biobank
QSkin Sun and Health Study
Taiwan Biobank
HUNT Study
UCLA ATLAS Community Health Initiative
Uganda Genome Resource
UK Biobank
Alicia R MartinAnalytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Cristen J WillerDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Mark J DalyAnalytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Benjamin M NealeAnalytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
deCODE Genetics (Iceland) · ISBroad Institute · USUniversity of Michigan · USUniversity of Colorado Anschutz Medical Campus · USQatar Foundation · QAUniversity of Pennsylvania · USUniversity of Bristol · GBUniversity of Groningen · NLVanderbilt University Medical Center · USNewLink Genetics (United States) · USQIMR Berghofer Medical Research Institute · AUUniversity Medical Center Groningen · NLUniversity of California, Los Angeles · USUniversity of Helsinki · FIEdinburgh Cancer Research · GBNorwegian University of Science and Technology · NOOntario Institute for Cancer Research · CAUniversidad de Morelia · MXUniversity of Oxford · GBUniversity of Tartu · EE
Funding
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3MUniversity of Michigan Training Program in Genomic ScienceT32HG000040 · NHGRI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Sebastian Zoellner · 1995 to 2026
$16.4MUsing genetics to discover mechanisms of myocardial infarctionR01HL109946 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI YUQING Eugene CHEN, Ida Liisa Surakka · 2011 to 2026
$8.9MIdentifying Genes for Type 2 Diabetes:FUSIONR01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2003 to 2025
$6.7MAn integrative approach to disease gene discovery combining genetic variation, gene expression, and epigenetics.R00HG012222 · NHGRI · MASSACHUSETTS GENERAL HOSPITAL · PI Wei Zhou · 2024 to 2026
$747kImproving Methods and Practices for Trans-Ethnic Genetic StudiesR56HG012354 · NHGRI · MASSACHUSETTS GENERAL HOSPITAL · PI GE, TIAN · 2022 to 2022
$475kAn integrative approach to disease gene discovery combining genetic variation, gene expression, and epigenetics.K99HG012222 · NHGRI · MASSACHUSETTS GENERAL HOSPITAL · PI ZHOU, WEI · 2022 to 2023
$319kPrecision Cardio-Metabolic Phenotyping for Genetic Discovery and Risk PredictionIK2CX001780 · VA · PHILADELPHIA VA MEDICAL CENTER · PI DAMRAUER, SCOTT MICHAEL · 2018 to 2023
–CSRD VA IK2 CX001780Medical Research Council MC_PC_13049Medical Research Council MC_PC_14135Medical Research Council MC_U137686851Medical Research Council MC_UU_00007/10Medical Research Council MC_UU_00011/1Medical Research Council MC_UU_00011/4Medical Research Council MC_UU_00017/1Medical Research Council MC_UU_12026/2NHGRI NIH HHS K99 HG012222NHGRI NIH HHS R00 HG012222NHGRI NIH HHS R56 HG012354NHGRI NIH HHS T32 HG000040NHLBI NIH HHS R01 HL109946NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK062370Wellcome Trust 210561/Z/18/ZWellcome Trust 212946/Z/18/Z
Abstract
Biobanks facilitate genome-wide association studies (GWASs), which have mapped genomic loci across a range of human diseases and traits. However, most biobanks are primarily composed of individuals of European ancestry. We introduce the Global Biobank Meta-analysis Initiative (GBMI)-a collaborative network of 23 biobanks from 4 continents representing more than 2.2 million consented individuals with genetic data linked to electronic health records. GBMI meta-analyzes summary statistics from GWASs generated using harmonized genotypes and phenotypes from member biobanks for 14 exemplar diseases and endpoints. This strategy validates that GWASs conducted in diverse biobanks can be integrated despite heterogeneity in case definitions, recruitment strategies, and baseline characteristics. This collaborative effort improves GWAS power for diseases, benefits understudied diseases, and improves risk prediction while also enabling the nomination of disease genes and drug candidates by incorporating gene and protein expression data and providing insight into the underlying biology of human diseases and traits.
Indexed as
ancestry diversitybiobankgenetic association studiesGWASmeta-analysisphenotype harmonization
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