Evidence map›Paper›PMID 36777868›Full record

ArticleAmerican journal of translational research2023

Paraneoplastic stiff-person syndrome with lung cancer: a case report and literature review.

Zhao Li, Di Han, Tong Chen, Lifang Zhang, Yan Wang, Yixuan Liu, Xuejuan Zhang

Abstract readCase Reports
In one paragraph

Article in American journal of translational research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhao LiDepartment of General Practice, Affiliated Hospital of Qingdao University Qingdao, Shandong, China.
Di HanDepartment of General Practice, Affiliated Hospital of Qingdao University Qingdao, Shandong, China.
Tong ChenDepartment of General Practice, Affiliated Hospital of Qingdao University Qingdao, Shandong, China.
Lifang ZhangDepartment of General Practice, Affiliated Hospital of Qingdao University Qingdao, Shandong, China.
Yan WangDepartment of General Practice, Affiliated Hospital of Qingdao University Qingdao, Shandong, China.
Yixuan LiuDepartment of Pathology, Affiliated Hospital of Qingdao University Qingdao, Shandong, China.
Xuejuan ZhangDepartment of General Practice, Affiliated Hospital of Qingdao University Qingdao, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stiff person syndrome is a rare autoimmune disease of the central nervous system that manifests as stiffness and painful spasms of the trunk axis and lower limb muscles. Benzodiazepines are the first choice for the clinical treatment of the disease. We reported a case of SPS. The patient presented with stiffness and convulsions of lower limbs, weakness after convulsions, falling off easily, abdominal muscle stiffness, and painful spasms lasting for several minutes and alleviating spontaneously. This was caused or aggravated by fatigue or mental stimulation. Left stiffness and weakness of the muscle after relief was present. A chest-enhanced computed tomography scan (CT) suggested two large ground glass nodules in the upper lobe of the left lung. Biopsy pathology indicated the nodules as adenocarcinoma in situ. The patient's symptoms were significantly relieved after treatment with clonazepam and diazepam combined with pregabalin. The clinical manifestations of SPS vary among patients. The symptoms of the disease are mild or severe. Early identification and treatment can improve the prognoses of these patients.

Indexed as

anti-GAD65autoimmune responsebenzodiazepineslung cancerparaneoplastic syndromeStiff person syndrome (SPS)

Identifiers

PMID36777868
PMCPMC9908479

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.